Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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Hepatitis and liver cancer: a national strategy for prevention and control of hepatitis B and C.
TL;DR: Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of chronic hepatitis B and hepatitis C infections as discussed by the authors, and presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis.
BASIC—LIVER, PANCREAS, AND BILIARY TRACT Human Immunodeficiency Virus-Related Microbial Translocation and Progression of Hepatitis C
Ashwin Balagopal,Frances H. Philp,Jacquie Astemborski,Timothy M. Block,Anand Mehta,Ronald E. Long,Gregory D. Kirk,Shruti H. Mehta,Andrea L. Cox,David L. Thomas,Stuart C. Ray +10 more
TL;DR: Microbial translocation may be a fundamental mechanism through which HIV accelerates progression of chronic liver disease.
Journal ArticleDOI
Hepatocellular carcinoma in HIV-infected patients: epidemiological features, clinical presentation and outcome.
Massimo Puoti,Raffaele Bruno,Soriano,Francesco Donato,G.B. Gaeta,G.P. Quinzan,D. Precone,Umberto Gelatti,Asensi,E. Vaccher +9 more
TL;DR: HCC in HIV-infected patients is mainly associated with underlying chronic hepatitis C and has a more aggressive clinical course, so preventative strategies (including the treatment of hepatitis C) should be implemented in the management of HIV/HCV-coinfected patients.
Journal ArticleDOI
Effective therapy has altered the spectrum of cause-specific mortality following HIV seroconversion.
Colette Smit,Ronald B. Geskus,Sarah Walker,Caroline A. Sabin,Roel A. Coutinho,Kholoud Porter,Maria Prins +6 more
TL;DR: Overall and cause specific mortality decreased following the introduction of HAART, and OI remain the most common COD in the HAART era, suggesting that AIDS-related events will continue to be important in the future.
Journal ArticleDOI
Natural History of Hepatitis B Virus Infection: An Update for Clinicians
TL;DR: The importance of monitoring all patients with chronic HBV infection to identify candidates for and select optimal timing of antiviral treatment, to recognize those at risk of complications, and to implement surveillance for early detection of hepatocellular carcinoma is emphasized.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
Journal ArticleDOI
The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
Journal ArticleDOI
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.