Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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Five-year review of HIV-hepatitis B virus (HBV) co-infected patients in a New York City AIDS center.
TL;DR: Use of dual active antiretrovirals, particularly, tenofovir (TDF) based regimen for optimal suppression of HIV-HBV and immune restoration with prevention of high risk behaviors may contribute to improved outcomes.
Journal ArticleDOI
Chronic hepatitis B increases mortality and complexity among HIV-coinfected patients in South Africa: a cohort study.
Kavindhran Velen,Salome Charalambous,Craig Innes,Gavin J. Churchyard,Christopher J. Hoffmann +4 more
TL;DR: To assess the effect of chronic hepatitis B on survival and clinical complexity among people living with HIV following antiretroviral therapy (ART) initiation, a large number of people were randomly assigned to receive ART or placebo.
Journal ArticleDOI
Low Prevalence of Liver Disease but Regional Differences in HBV Treatment Characteristics Mark HIV/HBV Co-Infection in a South African HIV Clinical Trial
Prudence Ive,William B. MacLeod,William B. MacLeod,Nompumelelo Mkumla,Catherine Orrell,Ute Jentsch,Carole L. Wallis,Wendy Stevens,Robin Wood,Ian Sanne,Debika Bhattacharya +10 more
TL;DR: One third of HIV/ HBV co-infected subjects had low HBV DNA levels and ALT while the majority had indicators of only mild liver disease, highlighting the absence of severe liver disease and the marked regional differences in HIV/HBVCo-infection in South Africa.
Journal ArticleDOI
Chronic coinfection with hepatitis B and hepatitis C viruses in an Italian population of HIV-infected patients.
Salvatore Sollima,Ilaria Caramma,Barbara Menzaghi,Benedetta Massetto,Veronica Acquaviva,Giuseppe Giulani,Mauro Moroni,Spinello Antinori +7 more
TL;DR: The prevalence of chronic coinfection with HBV and HCV in a large cohort of HIV-infected persons and to investigate the replicative patterns of both viruses in such patients is estimated.
Journal ArticleDOI
Management of hepatitis B in patients coinfected with the human immunodeficiency virus.
R Lessells,Clifford Leen +1 more
TL;DR: Combination therapy with lamivudine and tenofovir has shown promise and is currently being investigated in clinical trials, while new drugs and other combinations are in development.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
Journal ArticleDOI
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.