Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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HBV Infection in HIV-Driven Immune Suppression
TL;DR: The main aspects of HBV infection in HIV-positive patients are summarized, emphasizing the importance of carefully considering the coinfected patient in the context of therapeutic strategies of antiretroviral therapy.
Journal ArticleDOI
Influence of HIV-associated degree of immune suppression on molecular heterogeneity of hepatitis B virus among HIV co-infected patients.
Ananya Pal,Rajesh Panigrahi,Avik Biswas,Sibnarayan Datta,Neelakshi Sarkar,Subhashish Kamal Guha,Bibhuti Saha,Arup Banerjee,Sekhar Chakrabarti,Runu Chakravarty +9 more
TL;DR: Cutting genetic diversity and increased viral load in the HBV/D2 isolates might facilitate the maintenance of their wild type characteristics in the low CD4 count, leading to its increased prevalence in this group.
Journal ArticleDOI
The burden of hepatitis B virus (HBV) infection, genotypes and drug resistance mutations in human immunodeficiency virus-positive patients in Northwest Ethiopia.
Tekalign Deressa,Debasu Damtie,Kevin Fonseca,Shan Gao,Ebba Abate,Shitaye Alemu,Yetemwork Aleka,Mark G. Swain,Guido van Marle,Carla S. Coffin +9 more
TL;DR: The prevalence of HBV, HBV genotypes, and drug resistance mutations in dual infected cases in a cohort of HIV patients in Northwest Ethiopia found 5.5% HBV/HIV co-infected cases, underscoring the importance of integrating HBV screening to the HIV treatment guidelines for better management and prevention ofHBV-related liver disease.
Journal ArticleDOI
Factors influencing liver disease progression in chronic hepatitis B
Yun-Fan Liaw,Jose D. Sollano +1 more
TL;DR: An enhanced understanding of factors associated with HBV disease progression may lead to improvements in the selection of candidates for intervention and overall disease management.
Journal ArticleDOI
Antiretroviral therapy : pharmacokinetic considerations in patients with renal or hepatic impairment.
Sarah M McCabe,Qing Ma,Judianne C. Slish,Linda M. Catanzaro,Neha Sheth,Robert DiCenzo,Gene D. Morse +6 more
TL;DR: The current knowledge of the use of antiretrovirals in patients with hepatic or renal impairment is summarized, and dosing recommendations for this subpopulation of HIV-infected patients are made.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
Journal ArticleDOI
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.