Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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Hepatitis C Virus (HCV) Quasispecies Complexity and Selection in HCV/HIV-Coinfected Subjects Treated with Interferon-Based Regimens
Kenneth E. Sherman,Susan D. Rouster,Sandra Stanford,Jason T. Blackard,Norah J. Shire,Margaret James Koziel,Marion G. Peters,Raymond T. Chung +7 more
TL;DR: Baseline HCV complexity is an independent predictor of EVR in HCV/HIV-coinfected subjects and a decrease in complexity occurs by 4 weeks after the initiation of interferon-based therapy and is associated with RVR.
Journal ArticleDOI
Do HIV Care Providers Appropriately Manage Hepatitis B in Coinfected Patients Treated with Antiretroviral Therapy
Mamta K. Jain,Christopher K. Opio,Chukwuma C. Osuagwu,Rathi Pillai,Philip Keiser,William M. Lee +5 more
TL;DR: Improved physician adherence to guidelines that better delineate HBV treatment and monitoring for patients with HIV-HBV coinfection is needed.
Journal ArticleDOI
Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Scott Preiss,Margaret Littlejohn,Peter W Angus,Alexander J. Thompson,Paul V. Desmond,Sharon R Lewin,Joe Sasadeusz,Gail V. Matthews,Gregory J. Dore,Tim Shaw,V. Sozzi,Lilly Yuen,George K. K. Lau,Anna Ayres,Chloe L. Thio,Anchalee Avihingsanon,Kiat Ruxrungtham,Stephen Locarnini,Peter Revill +18 more
TL;DR: The results identified no association between dDNA and parameters associated with disease status and suggested that the relative abundance of dDNA is largely dependent on the integrity of the HBV polymerase and is unrelated to the severity of liver disease.
Journal ArticleDOI
Management of HIV infection in treatment-naive patients: a review of the most current recommendations.
TL;DR: The DHHS 2011 guidelines advocate earlier antiretroviral therapy initiation than recommended in recent years, and preferred regimens have been refined to maximize efficacy, safety, and quality of life for treatment-naive HIV-infected patients.
Journal ArticleDOI
Increasing Incidence of Recent Hepatitis D Virus Infection in HIV-Infected Patients in an Area Hyperendemic for Hepatitis B Virus Infection
Chien-Ching Hung,Shih-Min Wu,Pi-Han Lin,Wang-Huei Sheng,Zong-Yu Yang,Hsin-Yun Sun,Mao-Song Tsai,Kuan-Yeh Lee,Ming-Siang Huang,Shu-Fang Chang,Yi-Ching Su,Wen-Chun Liu,Sui-Yuan Chang +12 more
TL;DR: The findings show that the incidence of recent HDV infection in HIV/HBV-coinfected patients increased significantly from 1992-2001 to 2007-2011, and was associated with hepatitis flares and syphilis.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
Journal ArticleDOI
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.