Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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Drug-resistant and immune-escape HBV mutants in HIV-infected hosts.
TL;DR: For patients coinfected with HIV, hepatitis B treatment options that aim to reduce the risk of HBV mutations from emerging must be seriously considered, not only from clinical but also public health perspectives.
Journal ArticleDOI
Causes of hospitalization and predictors of HIV-associated mortality at the main referral hospital in Sierra Leone: a prospective study
Sulaiman Lakoh,Darlinda F. Jiba,Joseph E. Kanu,Eva Poveda,Ángel Salgado-Barreira,Foday Sahr,Momodu Sesay,Gibrilla F. Deen,Tom Sesay,Wadzani Gashau,Robert A. Salata,Robert A. Salata,George A. Yendewa,George A. Yendewa,George A. Yendewa +14 more
TL;DR: It is necessary to implement specific measures to enhance early HIV diagnosis and expand treatment access to all HIV-infected patients in Sierra Leone with a high morbidity and in-hospital mortality burden.
Journal ArticleDOI
Epidemiology of Liver Cancer in Africa: Current and Future Trends.
Edith N. Okeke,Pantong Davwar,Lewis R. Roberts,Kurt Sartorius,Wendy Spearman,Abraham O. Malu,Mary Duguru +6 more
TL;DR: A narrative review of HCC in Africa, discussing present and future trends is presented and the development of biomarkers and new therapeutic interventions will need a better understanding of the unique genetic and epigenetic characteristics of H CC on the continent.
Journal ArticleDOI
Addressing the global burden of hepatitis B virus while developing long-acting injectables for the prevention and treatment of HIV
Robert C. Bollinger,Chloe L. Thio,Mark S. Sulkowski,Jane McKenzie-White,David L. Thomas,Charles Flexner +5 more
TL;DR: Access to long-acting HIV drug formulations with dual activity against HBV would be transformative and have a great impact on efforts to prevent, treat, and eradicate both of these important global epidemics.
Journal ArticleDOI
Low frequency of liver enzyme elevation in HIV-infected patients attending a large urban treatment centre in Uganda.
Ponsiano Ocama,Barbara Castelnuovo,Moses R. Kamya,Gregory D. Kirk,Steven J. Reynolds,Steven J. Reynolds,Agnes N. Kiragga,R Colebunders,David L. Thomas +8 more
TL;DR: Male gender and CD4+ change from baseline were correlated with AST elevation and patients with HIV/HBV co-infection were not at an increased risk of AST elevation, which occurred uncommonly in this setting.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
Journal ArticleDOI
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.