Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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Advancing our understanding of HIV co-infections and neurological disease using the humanized mouse
TL;DR: A review of current and future co-infection models to address important clinical and research questions are further discussed in this article, where the authors emphasize recent advances in modeling bacterial and viral co-infections in the setting of HIV in humanized mice, especially neurological disease, and Mycobacterium tuberculosis and HIV coinfections.
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Global burden of hepatitis B virus: current status, missed opportunities and a call for action
Journal ArticleDOI
Rilpivirine in the treatment of HIV infection: evidence from the ECHO and THRIVE studies
TL;DR: RPV was associated with fewer discontinuations due to adverse events and a better tolerability profile, particularly during treatment with antiretroviral treatment-naive, HIV-1-infected adults, and in patients with baseline viral load ≤100,000 copies/ml, virology failures rates were similar.
Journal ArticleDOI
CXCL-10, interleukin-12 and interleukin-21 are not immunological predictors of HBeAg seroconversion in HIV-1-HBV coinfection following HBV-active antiretroviral therapy.
Paola Giarda,Anchalee Avihingsanon,Joe Sasadeusz,Jennifer Audsley,P. Marks,Gail V. Matthews,Kiat Ruxrungtham,Sharon R Lewin,Megan Crane +8 more
TL;DR: No evidence was found that CXCL-10, IL-12 or IL-21 were associated with HBeAg seroconversion following HBV-active cART, and other immunological determinants should be explored in this setting.
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Organ Transplantation and HIV Progress or Success? A Review of Current Status.
TL;DR: After limited early experience and a recent large national trial, HIV organ transplantation has gained a degree of acceptance and the progress and unresolved issues are reviewed.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
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Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.