Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052
Amy E. Greer,San San Ou,Ethan Wilson,Estelle Piwowar-Manning,Michael Forman,Marybeth McCauley,Theresa Gamble,Cholticha Ruangyuttikarn,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,Mulinda Nyirenda,Beatriz Grinsztejn,José Henrique Pilotto,Natthapol Kosashunhanan,Marineide Gonçalves de Melo,Joseph Makhema,Victor Akelo,Victor Akelo,Ravindre Panchia,Sharlaa Badal-Faesen,Ying Q. Chen,Myron S. Cohen,Susan H. Eshleman,Chloe L. Thio,Alexandra Valsamakis +24 more
TL;DR: HBV infection status did not differ by HIV infection status, and HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA.
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CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.
Nobuyo Higashi-Kuwata,Sanae Hayashi,Debananda Das,Satoru Kohgo,Shuko Murakami,Shin-ichiro Hattori,Shuhei Imoto,David Venzon,Kamalendra Singh,Stefan G. Sarafianos,Yasuhito Tanaka,Hiroaki Mitsuya,Hiroaki Mitsuya +12 more
TL;DR: CMCdG potently inhibited HBV production in HepG2.2 and efficiently suppressed ETV-resistant HBVETV-RL180M/S202G/M204V (IC50, 2,657 nM), while it showed no or little cytotoxicity.
Journal ArticleDOI
Sero-prevalence of Hepatitis B and C viral co-infections among HIV-1 infected ART-naïve individuals in Kumasi, Ghana.
Richard Boateng,Mohamed Mutocheluh,Albert Dompreh,Dorcas Obiri-Yeboah,Enoch Odame Anto,Michael Owusu,Patrick Williams Narkwa +6 more
TL;DR: The present study highlights the predominance of HBV exposure among the HIV infected patients in Ghana and indicates that HBV coinfection was associated with severe immunosuppression and higher HIV-1 viral load.
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Seroprevalence of hepatitis B in a cohort of HIV-infected children and adults in Swaziland
Eric J. Dziuban,Eric J. Dziuban,Stephanie Marton,Allison B. Hughey,T L Mbingo,Heather R. Draper,Heather R. Draper,Gordon E. Schutze,Gordon E. Schutze +8 more
TL;DR: Given the number of patients found to be HBsAg-positive, especially among adults, it is important for antiretroviral programmes to consider universal screening and strategically utilize medications that have been found effective in treating both HBV and HIV.
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Brief Report: Heplisav-B Seroprotection in People With HIV: A Single-Center Experience
TL;DR: In the first single-center retrospective study of Heplisav-B in PWH, the SPR compared favorably to the SPR seen among PWH from prior HBV vaccines across key subgroups.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
Journal ArticleDOI
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.