Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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The management of hepatitis B virus/HIV-1 co-infected patients starting their first HAART regimen. Treating two infections for the price of one drug?
Massimo Puoti,Alessandro Cozzi-Lepri,Fausto Ancarani,Raffaele Bruno,Silvia Ambu,Teresa Ferraro,Paolo Tundo,Teresa Santantonio,Mario Toti,Marino Bonasso,AD Monforte +10 more
TL;DR: Patients treated with a lamivudine-containing highly active antiretroviral therapy regimen starting their first HAART regimen showed a significantly lower level of alanine aminotransferase over follow-up and a significantly reduced risk of liver-related morbidity/mortality.
Journal ArticleDOI
Outcomes in HIV/HBV-Coinfected Patients in the Tenofovir Era Are Greatly Affected by Immune Suppression.
Andrew J. Huang,Marina Núñez +1 more
TL;DR: Mortality was high and most often unrelated to liver disease in this HIV/HBV-Coinfected cohort treated predominantly with TDF-containing HAART, and Optimal CD4 counts predicted survival and the achievement of HBV virological end points.
Journal ArticleDOI
The management of Hiv and hepatitis B coinfection
TL;DR: A review of the most important recent developments in the management of HIV and hepatitis B virus coinfection is presented in this paper, where strategies for use of these new options for anti-hepatitis B virus therapy in coinfected individuals are discussed.
Journal ArticleDOI
Tratamiento antirretroviral de la infección por el VIH
Fernando Lozano,Pere Domingo +1 more
TL;DR: El tratamiento antirretroviral, si bien no puede erradicar la infeccion por el VIH, mantiene suprimida la replicacion viral, incrementa el numero of linfocitos CD4+, disminuye la morbimortalidad, mejora the calidad of vida and previene the transmision sexual del VIH.
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Hepatitis B virus infection among pregnant women in Haiti: A cross-sectional serosurvey.
Rania A. Tohme,Jocelyne Andre-Alboth,Alexandra Tejada-Strop,Ran Shi,Jacques Boncy,Jeannot Francois,Jean Wysler Domercant,Mark Griswold,Erlantz Hyppolite,Paul Adrien,Saleem Kamili +10 more
TL;DR: Haiti has an intermediate endemicity of chronic HBV infection with high prevalence of positive HBV DNA among chronically infected women and introduction of a universal birth dose of hepatitis B vaccine might help prevent perinatal HBV transmission.
References
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Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
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Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.