Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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Prevalence of Chronic Hepatitis B and Incidence of Acute Hepatitis B Infection in Human Immunodeficiency Virus–Infected Subjects
TL;DR: HBV rates in this population were much higher than those in the general population, and vaccination levels were low, but ART and vaccination are associated with decreased disease.
Journal ArticleDOI
Increasing burden of liver disease in patients with HIV infection
TL;DR: An overview of the key causes, disease mechanisms of pathogenesis, and recommendations for treatment options including the evolving role of liver transplantation are provided.
Journal ArticleDOI
Human Immunodeficiency Virus-Related Microbial Translocation and Progression of Hepatitis C
Ashwin Balagopal,Frances H. Philp,Jacquie Astemborski,Timothy M. Block,Anand Mehta,Ronald E. Long,Gregory D. Kirk,Shruti H. Mehta,Andrea L. Cox,David L. Thomas,Stuart C. Ray +10 more
TL;DR: In this article, the authors found that HIV-related CD4 + lymphocyte depletion was associated with enhanced microbial translocation, and microbial translocated is a mechanism through which alcohol and some enteric conditions cause liver disease.
Journal ArticleDOI
The role of HIV in serious diseases other than AIDS.
TL;DR: This work describes and understands what residual clinical effects of HAART in resource-rich countries are and how these effects are changing over the course of a decade.
Journal ArticleDOI
Efficacy of Tenofovir Disoproxil Fumarate in Antiretroviral Therapy-Naive and -Experienced Patients Coinfected with HIV-1 and Hepatitis B Virus
Gregory J. Dore,David A. Cooper,Anton Pozniak,Edwin DeJesus,Lijie Zhong,Michael D. Miller,Biao Lu,Andrew K. Cheng,Study Teams +8 more
TL;DR: Tenofovir DF has potent anti-HBV efficacy in antiretroviral therapy-experienced and -naive individuals coinfected with HIV and HBV.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
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Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.