HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
Citations
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HIV-1 Tat and HIV-associated Dementia
Zhou Qin-Hua,Yao Xin +1 more
TL;DR: Growing evidence indicates that HIV-1 Tat protein play a major role in pathogenesis of HAD, the most severe form of HIV-related neuropsychiatric impairment and is characterized by motor dysfunction and impaired cognitions and behaviors.
Journal ArticleDOI
Neurological complications of HIV
TL;DR: HIV is neurotropic and causes a neurocognitive disorder as well as vacuolar myelopathy and treatment itself can be associated with neurological complications, particularly neuropathy, and, due to alterations in lipid metabolism, cerebrovascular disease.
Journal ArticleDOI
Nanomedicines encountering HIV dementia: A guiding star for neurotherapeutics
TL;DR: In this article , the authors proposed a method to circumvent this limitation by effective drug targeting (CNS) and crossing BBB, which has specific impact on toxicological consequences of nanomedicines.
Book ChapterDOI
HIV Co-receptors: The Brain Perspective
TL;DR: The role of chemokines and chemokine receptors in HIV-1 infection and the pathogenesis of AIDS and HIVD is discussed and potential therapeutic strategies are briefly detailed.
References
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Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection
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Roger Detels,Alvaro Muñoz,Glen McFarlane,Lawrence A. Kingsley,Joseph B. Margolick,Janis V. Giorgi,Lewis K. Schrager,John P. Phair +7 more
TL;DR: In the calendar period when potent antiretroviral therapy was introduced, the time to development of AIDS and time to death were extended, and rate of CD4 cell count decline was arrested.
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