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Open AccessJournal ArticleDOI

HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998

Ned Sacktor, +8 more
- 23 Jan 2001 - 
- Vol. 56, Iss: 2, pp 257-260
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.
Abstract: 
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.

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Citations
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Journal ArticleDOI

Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice.

Paul J. Pistell, +9 more
- 01 Dec 2010 - 
TL;DR: Results indicate that repeated lopinavir/ritonavir administration produces cognitive as well as metabolic impairments, and suggest that the development of selective aspects of metabolic syndrome in HIV patients could contribute to HIV-associated neurocognitive disorders.
Journal ArticleDOI

Neurological complications in AIDS patients receiving HAART: a 2-year retrospective study.

K. Subsai, +5 more
- 01 Mar 2006 - 
TL;DR: The overall incidence of NIRIS, including progressive multifocal leukoencephalopathy (PML), cerebral toxoplasmosis and cytomegalovirus (CMV) retinitis, was lower than the previous incidence of AIDS‐defining disease in the pre‐HAART era, however, the incidence of ischemic stroke, hemorrhagic stroke and primary central nervous system (CNS) lymphoma had increased.
Journal ArticleDOI

Sexually transmitted diseases and sexual function

Hossein Sadeghi-Nejad, +4 more
- 01 Jan 2010 - 
TL;DR: Major factors causing the spread of STIs are highlighted and management interventions to prevent further spread of HIV/STIs are suggested, focusing on the juxtaposition between STIs and sexual functioning.
Journal ArticleDOI

Potentiation of Excitotoxicity in HIV-1 Associated Dementia and the Significance of Glutaminase.

Nathan Erdmann, +2 more
- 01 Dec 2006 - 
TL;DR: Evidence suggests that poorly controlled generation of glutamate by phosphate-activated glutaminase may contribute to the neurotoxic state typical of HAD as well as other neurodegenerative disorders.
Journal ArticleDOI

HIV-related neurocognitive impairment – A review

Simon Rackstraw
- 26 Aug 2011 - 
TL;DR: This review will examine the recent changes in the understanding of the HIV-associated neurocognitive disorders (HAND) including the changing epidemiology, risk factors associated with its development, methods for screening for the disorders and evolving treatment options.
References
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Deborah A. Levy, +4 more
- 11 Dec 1998 - 
TL;DR: In this paper, the authors reported a total of 22 waterborne-disease outbreaks associated with drinking water and recreational lake water, which caused an estimated total of 2,567 persons to become ill. No deaths were reported.
Journal ArticleDOI

The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants

Richard A. Kaslow, +5 more
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TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI

Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection

Robert S. Janssen, +29 more
- 01 Jun 1991 - 
TL;DR: These definitions have been developed in conjunction with the International Classification of Diseases-10 (ICD-10, unpublished draft of the World Health Organization) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV, unpublishedDraft of the American Psychiatric Association) and are not identical.
Journal ArticleDOI

Effectiveness of Potent Antiretroviral Therapy on Time to AIDS and Death in Men With Known HIV Infection Duration

Roger Detels, +7 more
- 04 Nov 1998 - 
TL;DR: In the calendar period when potent antiretroviral therapy was introduced, the time to development of AIDS and time to death were extended, and rate of CD4 cell count decline was arrested.
Journal ArticleDOI

Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapy.

H. R. Brodt, +5 more
- 15 Nov 1997 - 
TL;DR: The incidence of AIDS-defining events in patients with advanced HIV infection at Frankfurt University Hospital has declined by more than 70% from 1992 to 1996, with a trend for malignancies and single opportunistic infections, with the exception of mycobacterial diseases.
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