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Open AccessJournal ArticleDOI

HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998

TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.
Abstract
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.

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Journal ArticleDOI

HIV-1-assoziierte neurokognitive Störung

TL;DR: By restoring the immunological function the modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has considerably lowered the incidence of opportunistic infections.
Journal ArticleDOI

Primäres ZNS-Lymphom während der Behandlung von Autoimmunerkrankungen mit Azathioprin : Kasuistik und Literaturübersicht

TL;DR: The risk of primary non-Hodgkin lymphoma under azathioprine treatment for an autoimmune disease with a possible congenital immunodeficiency is presented and the literature is reviewed as discussed by the authors.
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Journal Article

Surveillance for waterborne-disease outbreaks : united states, 1995-1996

TL;DR: In this paper, the authors reported a total of 22 waterborne-disease outbreaks associated with drinking water and recreational lake water, which caused an estimated total of 2,567 persons to become ill. No deaths were reported.
Journal ArticleDOI

The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants

TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI

Effectiveness of Potent Antiretroviral Therapy on Time to AIDS and Death in Men With Known HIV Infection Duration

TL;DR: In the calendar period when potent antiretroviral therapy was introduced, the time to development of AIDS and time to death were extended, and rate of CD4 cell count decline was arrested.
Journal ArticleDOI

Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapy.

TL;DR: The incidence of AIDS-defining events in patients with advanced HIV infection at Frankfurt University Hospital has declined by more than 70% from 1992 to 1996, with a trend for malignancies and single opportunistic infections, with the exception of mycobacterial diseases.
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