HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
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Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions.
TL;DR: The extraordinary frequency with which PML attends HIV infection vastly exceeds its appearance in association with other predisposing conditions and has resulted in it no longer being considered a rare disorder.
Journal ArticleDOI
HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era.
Lucy Garvey,Lucy Garvey,Alan Winston,Alan Winston,John Walsh,Frank A. Post,Kholoud Porter,Brian Gazzard,Martin Fisher,Clifford Leen,Deenan Pillay,Teresa Hill,Margaret Johnson,Richard Gilson,Jane Anderson,Philippa Easterbrook,Loveleen Bansi,Chloe Orkin,Jonathan Ainsworth,Andrew N. Phillips,Caroline A. Sabin,UK Collaborative Hiv Cohort Chic +21 more
TL;DR: This data indicates that the incidence and survival of HIV‐related central nervous system diseases (CNS‐D) in recent years are sparse and need to be investigated further to establish a causative mechanism.
Journal ArticleDOI
Cerebral toxoplasmosis in HIV-positive patients in Brazil: clinical features and predictors of treatment response in the HAART era.
José E. Vidal,Adrian V. Hernandez,Augusto C. Penalva de Oliveira,Rafi F. Dauar,Silas Pereira Barbosa,Roberto Focaccia +5 more
TL;DR: In Brazilian patients with AIDS, cerebral toxoplasmosis mainly occurs as an AIDS-defining disease, and causes significant morbidity and mortality, and signs of neurologic deterioration predict an unfavorable response to the treatment.
Journal ArticleDOI
The impact of HIV-protease inhibitors on opportunistic parasites
TL;DR: The results of studies on opportunistic parasitic infections conducted both before and during the HAART era indicate the need to develop clinical trials on the efficacy of HIV protease inhibitors in controlling parasitic infections in individuals with HIV or other immunocompromised individuals and laboratory investigations on aspartyl proteases of parasites as an important target for the development of new drugs.
Journal ArticleDOI
Loss of the N-linked glycosylation site at position 386 in the HIV envelope V4 region enhances macrophage tropism and is associated with dementia
Rebecca L. Dunfee,Elaine R. Thomas,Jianbin Wang,Kevin J. Kunstman,Steven M. Wolinsky,Dana Gabuzda +5 more
TL;DR: An HIV Env variant in the V4 region of gp120, Asp 386 (D386), is identified that eliminates an N-linked glycosylation site at position 386, enhances viral replication in macrophages, and is present at a higher frequency in AIDS patients with HIV-associated dementia (HAD) compared with non-HAD patients.
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Roger Detels,Alvaro Muñoz,Glen McFarlane,Lawrence A. Kingsley,Joseph B. Margolick,Janis V. Giorgi,Lewis K. Schrager,John P. Phair +7 more
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