HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
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Cerebral Toxoplasmosis in Adult Patients with HIV Infection
TL;DR: A 38-year-old woman presented to the emergency department with headache, a 5-day history of dizziness, and a 2- to 3- day history of nausea/vomiting and a presumptive diagnosis of cerebral toxoplasmosis due to reactivation of previous infection was made.
Anti-HIV Drugs Nevirapine and Efavirenz Affect Anxiety-Related Behavior and Cognitive Performance in Mice Pedro R. T. RomaoJoelson C. LemosJeverson MoreiraGisele de Chaves • Morgana MorettiAdalberto A. CastroVanessa M. Andrade • Carina R. BoeckJoao QuevedoElaine C. Gavioli
Rua Sarmento Leite,E. C. Gavioli +1 more
TL;DR: In this article, the effects of chronic administration of EFV (10 mg/kg) and NVP (3.3 mg/ kg) in mice submitted to two distinct series of experiments, which aimed to evaluate: (1) the emotional behavior (elevated plus-maze, forced swimming,and open-armed test) and (2) the cognitive performance(object recognition and inhibitory avoidance test) of mice.
Journal ArticleDOI
Screening for Neurocognitive Impairment in HIV-Infected Individuals at First Contact after HIV Diagnosis: The Experience of a Large Clinical Center in Northern Italy.
Emanuele Focà,Paola Magro,Davide Motta,Silvia Compostella,Salvatore Casari,Andrea Bonito,Nigritella Brianese,Alice Ferraresi,Paola Rodari,Maria Chiara Pezzoli,Eugenia Quiros-Roldan,Francesco Castelli +11 more
TL;DR: The data suggest that patient-specific factors and AIDS diagnosis have a certain kind of impact in HAND occurrence, and a complete neuropsychological screening must be recommended in all patients at HIV-infection diagnosis.
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Longitudinal Analysis of Monocyte/Macrophage Infection in Simian Immunodeficiency Virus-Infected, CD8+ T-Cell-Depleted Macaques that Develop Lentiviral Encephalitis
TL;DR: In this article, the authors examined the relationship between peripheral SIV infection of monocytes/macrophages and the development of encephalitis and observed that monocyte-derived macrophages from these macaques produced more virus than those from macaques that did not.
References
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Journal Article
Surveillance for waterborne-disease outbreaks : united states, 1995-1996
TL;DR: In this paper, the authors reported a total of 22 waterborne-disease outbreaks associated with drinking water and recreational lake water, which caused an estimated total of 2,567 persons to become ill. No deaths were reported.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection
Robert S. Janssen,David R. Cornblath,Leon G. Epstein,Richard P. Foa,Justin C. McArthur,Richard W. Price,Arthur K. Asbury,Alexandra Beckett,D. Frank Benson,T.Peter Bridge,Carl M. Leventhal,Paul Satz,Andrew J. Saykin,John J. Sidtis,Susan Tross,James T. Becker,Kenneth G. Castro,Bruce A. Cohen,Marshall F. Folstein,Francisco Gonzalez-Scarano,Igor Grant,Mario Maj,R. H. McAllister,M.-Marsel Mesulam,Eric N. Miller,Margaret J. Oxtoby,Norman Sartorius,Ola A. Selnes,Janet B. W. Williams,Michael Zaudig +29 more
TL;DR: These definitions have been developed in conjunction with the International Classification of Diseases-10 (ICD-10, unpublished draft of the World Health Organization) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV, unpublishedDraft of the American Psychiatric Association) and are not identical.
Journal ArticleDOI
Effectiveness of Potent Antiretroviral Therapy on Time to AIDS and Death in Men With Known HIV Infection Duration
Roger Detels,Alvaro Muñoz,Glen McFarlane,Lawrence A. Kingsley,Joseph B. Margolick,Janis V. Giorgi,Lewis K. Schrager,John P. Phair +7 more
TL;DR: In the calendar period when potent antiretroviral therapy was introduced, the time to development of AIDS and time to death were extended, and rate of CD4 cell count decline was arrested.
Journal ArticleDOI
Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapy.
TL;DR: The incidence of AIDS-defining events in patients with advanced HIV infection at Frankfurt University Hospital has declined by more than 70% from 1992 to 1996, with a trend for malignancies and single opportunistic infections, with the exception of mycobacterial diseases.
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