HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
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Journal ArticleDOI
The Pathogenesis of HIV-Associated Dementia: Recent Advances Using a SCID Mouse Model of HIV-Encephalitis
Jennifer Cook,William R. Tyor +1 more
TL;DR: Human and animal studies suggest that viral strains may also be important in the pathogenesis of HAD, and a recent study suggests that HAART does not eradicate virus in the brain, and therefore, the CNS is a reservoir for HIV.
Journal ArticleDOI
Anti-HIV drugs promote β-amyloid deposition and impair learning and memory in BALB/c mice
TL;DR: Chronic exposure to TDF and nevirapine contributes to hippocampal lipid peroxidation and Aβ accumulation, respectively, as well as spatial learning and memory deficits in mice even in the absence of HIV infection, which further support a possible link between ARV drug toxicity, A β accumulation and the persistence of HANDs.
Journal ArticleDOI
Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson's disease.
Eva M. Müller-Oehring,Eva M. Müller-Oehring,Rosemary Fama,Rosemary Fama,Taylor F. Levine,Cheshire Hardcastle,Ryan Goodcase,Talora Martin,Varsha Prabhakar,Helen Bronte-Stewart,Kathleen L. Poston,Edith V. Sullivan,Tilman Schulte,Tilman Schulte +13 more
TL;DR: The motor-cognitive score relation in HIV provides further support for the hypothesis that these processes share similar underlying mechanisms in HIV infection possibly expressed with or exacerbated by ageing.
Journal Article
Long term management of people with HIV.
TL;DR: The management of stable patients with HIV is reviewed to provide an approach to important elements of their ongoing care, including mental health, drug and alcohol use, sexual and reproductive health and malignancies.
Book ChapterDOI
Cultural Neuropsychology Considerations in the Diagnosis of HIV-Associated Neurocognitive Disorders.
Monica Rivera Mindt,Monica Rivera Mindt,Desiree Byrd,Desiree Byrd,Emily P Morris,Emily P Morris,Kayla Tureson,Kayla Tureson,Vanessa A. Guzman,Vanessa A. Guzman,Angela C. Summers,Angela C. Summers,Cara L. Crook,Cara L. Crook,Micah J. Savin,Micah J. Savin,Maral Aghvinian,Maral Aghvinian +17 more
TL;DR: This chapter reviews HIV-related health disparities faced by CALD populations with focus on North American research where it has been specifically studied, with particular attention given to disparities in HIV-Associated Neurocognitive Disorders (HAND).
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