HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
Citations
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Detection of anti-tat antibodies in CSF of individuals with HIV-associated neurocognitive disorders.
TL;DR: An indirect enzyme-linked immunosorbent assay is developed and measured anti-Tat antibody titers in CSF of a well characterized cohort of 52 HIV-infected and 13 control individuals, finding that this robust immune response against the protein may be neuroprotective.
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Pathological findings in the central nervous system of AIDS patients on assumed antiretroviral therapeutic regimens: retrospective study of 1597 autopsies
Luca Vago,Sara Bonetto,Manuela Nebuloni,Piergiorgio Duca,Luca Carsana,Pietro Zerbi,Antonella D'Arminio-Monforte +6 more
TL;DR: These neuropathological data from a large autopsy series confirm clinical observations concerning the efficacy of antiretroviral treatment in reducing the frequency of HIV-related CNS lesions in AIDS patients.
Journal ArticleDOI
Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection
Michael R. Weed,Lisa H. Gold,Lisa H. Gold,Ilham Polis,George F. Koob,Howard S. Fox,Michael A. Taffe +6 more
TL;DR: The results further demonstrate the similarity of behavioral impairment produced by SIV and HIV on homologous behavioral tests, and establish the utility of the testing battery for further investigations into the CNS mechanisms of the reported behavioral changes.
Journal ArticleDOI
Cognitive Neurorehabilitation of HIV-associated Neurocognitive Disorders: A Qualitative Review and Call to Action
TL;DR: This qualitative review summarizes and critiques the emerging literature on cognitive and behavioral treatments for HAND, which provides many reasons for optimism, but also has major limitations that underscore the scope of the work that lies ahead.
Journal ArticleDOI
Platelet-derived growth factor protects neurons against gp120-mediated toxicity
Fuwang Peng,Navneet K. Dhillon,Shannon Callen,Honghong Yao,Sirosh Bokhari,Xuhui Zhu,Hicham H. Baydoun,Shilpa Buch +7 more
TL;DR: PDGF-BB could be considered as a therapeutic agent that can mitigate gp120-mediated neurotoxicity in HAD, and PDGF-mediated protection against gp120 involved the phosphoinositide 3-kinase/Akt pathway.
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