HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
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Primary central nervous system lymphoma (pcnsl), retrospective analysis of combined chemo-radiation using high dose methotrexate, experience from a single institute
TL;DR: A retrospective study supports other phase II trials results that high dose methotrexate followed by WBI in PCNSL improves outcome, and reveals that age and response had impact on OS and EFS.
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Clinical features and course of 5 cases with HIV encephalopathy
TL;DR: HIV encephalopathy was one of the presenting manifestations of HIV infection in four patients, and no patients had received antiretroviral therapy, and the functional prognosis was very poor.
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The Impact of the Drug Overdose Epidemic on the Mortality of Personswith HIV/AIDS
Alex F Manini,Cynthia D Santos +1 more
TL;DR: In the HAART era, AIDS-related causes of death declined, while deaths due to overdose significantly increased in HIV patients, and the rise in COMR was primarily attributable to pharmaceutical drugs for pain management.
Transcranial sonography of the third ventricle and cognitive dysfunction in HIV
Oliver Kastrup,Mark Obermann,Stefan Esser,Hans Wilhelm,Christian Ley,Michael Forsting,Matthias Maschke +6 more
TL;DR: In this paper, the authors investigated the usefulness of transcranial sonographic (TCS)measurement of the third ventricle detection of brain atrophy inHIV patients and the correlation with neuropsychological deficits.
Book ChapterDOI
Human Immunodeficiency Virus Infections—Neurological Manifestations
Hadi Manji,R.J. Guiloff +1 more
TL;DR: The chapter discusses HIV-1-associated dementia (HAD), HIV-l vacuolar myelopathy, cryptococcal meningitis, cytomegalovirus, mycobacterium tuberculosis, and others.
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