HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
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HIV/AIDS and psychiatry: Towards the establishment of a pilot programme for detection and treatment of common mental disorders in people living with HIV/AIDS in Cape Town
TL;DR: It is argued that the role of mental health in ARV programmes is central, and screening tools for mental disorders should be incorporated into routine ARV care, with support from dedicated HIV mental health services.
Book ChapterDOI
Public Health Importance of Cryptococcal Disease: Epidemiology, Burden, and Control
TL;DR: This chapter focuses primarily on HIV-associated cryptococcosis, due to its much greater public health burden, and discusses the challenges to public health agencies in addressing the threat of Cryptococcus gattii in North America.
Journal ArticleDOI
Chronic Viral Neuroinflammation: Speculation on Underlying Mechanisms.
TL;DR: This commentary addresses four questions: What drives the development of human immunodeficiency virus (HIV)-associated neurocognitive disorders, does the phenotype of macrophages in the CNS spur development of HIV encephalitis (HIVE), does continual activation of astrocytes drive theDevelopment of HIV-associated neuroCognitive disorders/subclinical disease, and neuroinflammation: friend or foe?
Book ChapterDOI
127 – Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections
Book ChapterDOI
HIV-1-Associated Neurocognitive Disorders in the HAART Era
TL;DR: Changes have occurred across the spectrum of HIV-1-associated neurocognitive disorders since the introduction of HAART, and both the neuropathological and the clinical aspects of the syndrome seem to be less severe than those observed in the pre-HAART era.
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Journal ArticleDOI
Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection
Robert S. Janssen,David R. Cornblath,Leon G. Epstein,Richard P. Foa,Justin C. McArthur,Richard W. Price,Arthur K. Asbury,Alexandra Beckett,D. Frank Benson,T.Peter Bridge,Carl M. Leventhal,Paul Satz,Andrew J. Saykin,John J. Sidtis,Susan Tross,James T. Becker,Kenneth G. Castro,Bruce A. Cohen,Marshall F. Folstein,Francisco Gonzalez-Scarano,Igor Grant,Mario Maj,R. H. McAllister,M.-Marsel Mesulam,Eric N. Miller,Margaret J. Oxtoby,Norman Sartorius,Ola A. Selnes,Janet B. W. Williams,Michael Zaudig +29 more
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Journal ArticleDOI
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