HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
Citations
More filters
Journal ArticleDOI
Prepulse inhibition in HIV-associated neurocognitive disorders.
Arpi Minassian,Brook L. Henry,Steven Paul Woods,Florin Vaida,Igor Grant,Mark A. Geyer,William Perry +6 more
TL;DR: Although HIV status alone was not associated with PPI deficits, HIV-positive participants meeting criteria for HAND showed impaired PPI compared to cognitively intact HIV- positive subjects, and PPI was correlated with working memory but was notassociated with antiretroviral therapy or illness factors.
Journal ArticleDOI
Issues in co-morbid severe mental illnesses in HIV infected individuals.
TL;DR: The assessment and management of four serious mental conditions in HIV-infected patients: delirium, dementia, schizophrenia and bipolar disorder are reviewed.
Journal ArticleDOI
The neuropathology of hiv infection in the era of highly active antiretroviral therapy (HAART)
Françoise Gray,Catherine Keohane +1 more
TL;DR: The pathological basis of HIV dementia is still a matter of debate, since none of the different HIV-specific CNS changes, HIV encephalitis, HIV leukoencephalopathy or diffuse poliodystrophy exactly correlates with the cognitive disorder.
Journal ArticleDOI
Neurocognitive impairment associated with predominantly early stage HIV infection in Abuja, Nigeria.
Christopher Akolo,Walter Royal,Mariana Cherner,Kanayo Okwuasaba,Lindsay M. Eyzaguirre,Ruxton Adebiyi,Anya Umlauf,Terence Hendrix,Joyce Johnson,Alash'le Abimiku,William A. Blattner +10 more
TL;DR: The ability of neuropsychological assessments to identify areas of impairment that may be specifically linked to a history of HIV infection among individuals in Nigeria is demonstrated.
Journal ArticleDOI
AIDS related opportunistic infections, going but not gone.
TL;DR: There have been dramatic improvements in diagnosis, prevention and treatment of all these infections over the last two decades, and as a result, in North America and Western Europe the rates of opportunistic infections secondary to AIDS have decreased substantially.
References
More filters
Journal Article
Surveillance for waterborne-disease outbreaks : united states, 1995-1996
TL;DR: In this paper, the authors reported a total of 22 waterborne-disease outbreaks associated with drinking water and recreational lake water, which caused an estimated total of 2,567 persons to become ill. No deaths were reported.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection
Robert S. Janssen,David R. Cornblath,Leon G. Epstein,Richard P. Foa,Justin C. McArthur,Richard W. Price,Arthur K. Asbury,Alexandra Beckett,D. Frank Benson,T.Peter Bridge,Carl M. Leventhal,Paul Satz,Andrew J. Saykin,John J. Sidtis,Susan Tross,James T. Becker,Kenneth G. Castro,Bruce A. Cohen,Marshall F. Folstein,Francisco Gonzalez-Scarano,Igor Grant,Mario Maj,R. H. McAllister,M.-Marsel Mesulam,Eric N. Miller,Margaret J. Oxtoby,Norman Sartorius,Ola A. Selnes,Janet B. W. Williams,Michael Zaudig +29 more
TL;DR: These definitions have been developed in conjunction with the International Classification of Diseases-10 (ICD-10, unpublished draft of the World Health Organization) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV, unpublishedDraft of the American Psychiatric Association) and are not identical.
Journal ArticleDOI
Effectiveness of Potent Antiretroviral Therapy on Time to AIDS and Death in Men With Known HIV Infection Duration
Roger Detels,Alvaro Muñoz,Glen McFarlane,Lawrence A. Kingsley,Joseph B. Margolick,Janis V. Giorgi,Lewis K. Schrager,John P. Phair +7 more
TL;DR: In the calendar period when potent antiretroviral therapy was introduced, the time to development of AIDS and time to death were extended, and rate of CD4 cell count decline was arrested.
Journal ArticleDOI
Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapy.
TL;DR: The incidence of AIDS-defining events in patients with advanced HIV infection at Frankfurt University Hospital has declined by more than 70% from 1992 to 1996, with a trend for malignancies and single opportunistic infections, with the exception of mycobacterial diseases.
Related Papers (5)
Updated research nosology for HIV-associated neurocognitive disorders
Andrea Antinori,Gabriele Arendt,James T. Becker,Bruce J. Brew,Desiree Byrd,Mariana Cherner,David B. Clifford,Paola Cinque,Leon G. Epstein,K. Goodkin,Magnus Gisslén,Igor Grant,Robert K. Heaton,Jeymohan Joseph,Karen Marder,Camillo Marra,Justin C. McArthur,Michael Nunn,Richard W. Price,Lynn Pulliam,Kevin Robertson,Ned Sacktor,Victor Valcour,Valerie Wojna +23 more
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study.
Robert K. Heaton,David B. Clifford,Donald Franklin,Steven Paul Woods,Christopher Ake,Florin Vaida,Ronald J. Ellis,S. Letendre,Thomas D. Marcotte,Joseph H. Atkinson,Monica Rivera-Mindt,Ofilio Vigil,Michael J. Taylor,Ann C. Collier,Camillo Marra,Benjamin B. Gelman,Justin C. McArthur,Susan Morgello,David M. Simpson,McCutchan Ja,Ian Abramson,Anthony Gamst,Christine Fennema-Notestine,Terry L. Jernigan,Joseph K. Wong,Igor Grant +25 more