HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Ned Sacktor,Robert H. Lyles,Richard L. Skolasky,C. Kleeberger,Ola A. Selnes,Eric N. Miller,James T. Becker,Bruce A. Cohen,Justin C. McArthur +8 more
TLDR
The proportion of new cases of HIV dementia with a CD4 count in a higher range since 1996 may be increasing, and the introduction of highly active antiretroviral therapy (HAART) may be responsible.Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.read more
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Assessment, Diagnosis, and Treatment of HIV-Associated Neurocognitive Disorder: A Consensus Report of the Mind Exchange Program
Andrea Antinori,Gabriele Arendt,Igor Grant,Scott Letendre,Jose A. Muñoz-Moreno,Christian Eggers,Bruce J. Brew,Marie-Josée Brouillette,Francisco Bernal-Cano,Adriana Carvalhal,Paulo Pereira Christo,Paola Cinque,Lucette A. Cysique,Ronald J. Ellis,Ian P. Everall,Jacques Gasnault,Ingo Husstedt,Volkan Korten,Ladislav Machala,Mark Obermann,Sílvia Ouakinin,Daniel Podzamczer,Peter Portegies,Simon Rackstraw,Sean B. Rourke,Lorraine Sherr,Adrian Streinu-Cercel,Alan Winston,Valerie Wojna,Yazdan Yazdanpannah,Gordon Arbess,Jean-Guy Baril,Josip Begovac,Colm Bergin,Paolo Bonfanti,Stefano Bonora,Kees Brinkman,Ana Canestri,Graźyna Cholewińska-Szymańska,Michal Chowers,John M. Cooney,Marcelo Corti,Colin P. Doherty,Daniel Elbirt,Stefan Esser,Eric Florence,Gilles Force,John Gill,Jean-Christophe Goffard,Thomas Harrer,Patrick C.K. Li,Linos Van de Kerckhove,Gaby Knecht,Shuzo Matsushita,Raimonda Matulionyte,Samuel J. McConkey,Antoine Mouglignier,Shinichi Oka,Augusto Penalva,Klaris Riesenberg,Helen Sambatakou,Valerio Tozzi,Matteo Vassallo,Peter Wetterberg,Alicia Wiercińska Drapato +64 more
TL;DR: The Mind Exchange program provides practical guidance in the diagnosis, monitoring, and treatment of HAND and identifies and develops practical answers to key clinical questions in HAND management.
Journal ArticleDOI
Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection.
TL;DR: The complex role(s) played by MP in the neuropathogenesis of HIV‐1 infection is reviewed, with particular emphasis given to the diversity of MP functions and how it may affect the disease process and manifestations.
Journal ArticleDOI
Increased Macrophage Chemoattractant Protein-1 in Cerebrospinal Fluid Precedes and Predicts Simian Immunodeficiency Virus Encephalitis
M. Christine Zink,Gary D. Coleman,Joseph L. Mankowski,Robert J. Adams,Patrick M. Tarwater,Kelly Fox,Janice E. Clements +6 more
TL;DR: The results suggest that the CSF:plasma MCP-1 ratio may be a valuable prognostic marker for the development of HIV-induced central nervous system disease.
Journal ArticleDOI
Focal neurological disease in patients with acquired immunodeficiency syndrome.
TL;DR: The combination of PCR and neuroimaging techniques may obviate the need for brain biopsy in selected cases and improve the prognosis of several focal CNS processes, most notably toxoplasmosis, PML, and CMV encephalitis.
Journal ArticleDOI
Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy: data from the Italian Registry Investigative Neuro AIDS (IRINA).
Andrea Antinori,Antonella Cingolani,Patrizia Lorenzini,Maria Letizia Giancola,Ilaria Uccella,Simona Bossolasco,Susanna Grisetti,Francesca Moretti,Beniamino Vigo,Marco Bongiovanni,Bruno Del Grosso,Maria Irene Arcidiacono,Giovanni Carlo Fibbia,Maurizio Mena,Maria Grazia Finazzi,Giovanni Guaraldi,Adriana Ammassari,Antonella d'Arminio Monforte,Paola Cinque,Andrea De Luca +19 more
TL;DR: Patients starting HAART at PML diagnosis and previously naïve for antiretrovirals showed significantly higher 1-year probability of survival, compared to those continuing HAART, or never receivingHAART, and higher CD4 cell count were associated with a higher survival probability.
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