Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats.
Rajangam Udayakumar,S. Kasthurirengan,Thankaraj Salammal Mariashibu,Manoharan Rajesh,Vasudevan Ramesh Anbazhagan,Sei Chang Kim,Andy Ganapathi,Chang Won Choi +7 more
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TLDR
Treatment of the diabetic rats withWSREt, WSLEt and glibenclamide restored the changes of the above parameters to their normal level after eight weeks of treatment, indicating that WSREt and WSLET possess hypoglycaemic and hypolipidaemic activities in alloxan-induced diabetes mellitus (DM) rats.Abstract:
Withania somnifera is an important medicinal plant, which is used in traditional medicine to cure many diseases. Flavonoids were determined in the extracts of W. somnifera root (WSREt) and leaf (WSLEt). The amounts of total flavonoids found in WSREt and WSLEt were 530 and 520 mg/100 g dry weight (DW), respectively. Hypoglycaemic and hypolipidaemic effects of WSREt and WSLEt were also investigated in alloxan-induced diabetic rats. WSREt and WSLEt and the standard drug glibenclamide were orally administered daily to diabetic rats for eight weeks. After the treatment period, urine sugar, blood glucose, haemoglobin (Hb), glycosylated haemoglobin (HbA1C), liver glycogen, serum and tissues lipids, serum and tissues proteins, liver glucose-6-phosphatase (G6P) and serum enzymes like aspartate transaminase (AST), alanine transaminase (ALT), acid phosphatase (ACP) and alkaline phosphatase (ALP) levels were determined. The levels of urine sugar, blood glucose, HbA1C, G6P, AST, ALT, ACP, ALP, serum lipids except high density lipoprotein-bound cholesterol (HDL-c) and tissues like liver, kidney and heart lipids were significantly (p < 0.05) increased, however Hb, total protein, albumin, albumin:globulin (A:G) ratio, tissues protein and glycogen were significantly (p < 0.05) decreased in alloxan-induced diabetic rats. Treatment of the diabetic rats with WSREt, WSLEt and glibenclamide restored the changes of the above parameters to their normal level after eight weeks of treatment, indicating that WSREt and WSLEt possess hypoglycaemic and hypolipidaemic activities in alloxan-induced diabetes mellitus (DM) rats.read more
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Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach
Bharat B. Aggarwal,Sahdeo Prasad,Simone Reuter,Ramaswamy Kannappan,Vivek R. Yadav,Byoungduck Park,Ji Hye Kim,Subash C. Gupta,Kanokkarn Phromnoi,Chitra Sundaram,Seema Prasad,Madan M. Chaturvedi,Bokyung Sung +12 more
TL;DR: Ayurveda, a science of long life, almost 6,000 years old, can serve as a "goldmine" for novel anti-inflammatory agents used for centuries to treat chronic diseases, and description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit are provided.
Journal ArticleDOI
Antidiabetic Potential of Medicinal Plants and Their Active Components.
Bahare Salehi,Athar Ata,Nanjangud V. Anil Kumar,Farukh Sharopov,Karina Ramírez-Alarcón,Ana M. Ruiz-Ortega,Seyed Abdulmajid Ayatollahi,Patrick Valere Tsouh Fokou,Farzad Kobarfard,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Marcello Iriti,Yasaman Taheri,Miquel Martorell,Antoni Sureda,William N. Setzer,Alessandra Durazzo,Massimo Lucarini,Antonello Santini,Raffaele Capasso,Elise Adrian Ostrander,Atta-ur-Rahman,Muhammad Iqbal Choudhary,William C. Cho,Javad Sharifi-Rad +24 more
TL;DR: Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies.
Journal ArticleDOI
Pharmacologic overview of Withania somnifera, the Indian Ginseng
TL;DR: Withania somnifera is a potential drug candidate to treat various clinical conditions, particularly related to the nervous system, and the mechanisms of action and potential therapeutic applications of the plant and its active constituents are discussed.
Journal ArticleDOI
Ethnobotanical studies of medicinal plants used by Traditional Health Practitioners in the management of diabetes in Lower Eastern Province, Kenya.
TL;DR: The findings of this study are important in the management of diabetes and future research on traditional medicine in drug development.
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