Immunology of COVID-19: Current State of the Science.
Nicolas Vabret,Graham J. Britton,Conor Gruber,Samarth Hegde,Joel Kim,Maria Kuksin,Rachel Levantovsky,Louise Malle,Alvaro Moreira,Matthew D. Park,Luisanna Pia,Emma Risson,Miriam Saffern,Bérengère Salomé,Myvizhi Esai Selvan,Matthew P. Spindler,Jessica Tan,Verena van der Heide,Jill Gregory,Konstantina Alexandropoulos,Nina Bhardwaj,Brian D. Brown,Benjamin Greenbaum,Zeynep H. Gümüş,Dirk Homann,Amir Horowitz,Alice O. Kamphorst,Maria A. Curotto de Lafaille,Saurabh Mehandru,Miriam Merad,Robert M. Samstein,Manasi Agrawal,Mark Aleynick,Meriem Belabed,Matthew Brown,Maria Casanova-Acebes,Jovani Catalan,Monica Centa,Andrew Charap,Andrew K Chan,Steven T. Chen,Jonathan Chung,Cansu Cimen Bozkus,Evan Cody,Francesca Cossarini,Erica Dalla,Nicolas F. Fernandez,John A. Grout,Dan Fu Ruan,Pauline Hamon,Etienne Humblin,Divya Jha,Julia Kodysh,Andrew Leader,Matthew Lin,Katherine E. Lindblad,Daniel Lozano-Ojalvo,Gabrielle Lubitz,Assaf Magen,Zafar Mahmood,Gustavo Martinez-Delgado,Jaime Mateus-Tique,Elliot Meritt,Chang Moon,Justine Noel,Timothy O'Donnell,Miyo Ota,Tamar Plitt,Venu Pothula,Jamie Redes,Ivan Reyes Torres,Mark P. Roberto,Alfonso R. Sanchez-Paulete,Joan Shang,Alessandra Soares Schanoski,Maria Suprun,Michelle Tran,Natalie Vaninov,C. Matthias Wilk,Julio A. Aguirre-Ghiso,Dusan Bogunovic,Judy H. Cho,Jeremiah J. Faith,Emilie K. Grasset,Peter S. Heeger,Ephraim Kenigsberg,Florian Krammer,Uri Laserson +87 more
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TLDR
The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.About:
This article is published in Immunity.The article was published on 2020-06-16 and is currently open access. It has received 1350 citations till now.read more
Citations
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Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.
TL;DR: The historical origins and the current state of the science of innate and adaptive immunity in aging and longevity are reviewed andGeroprotectors targeting these mechanisms are comprehensively discussed in this article.
Journal ArticleDOI
Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell Impairment.
Jia Liu,Xuecheng Yang,Hua Wang,Ziwei Li,Hui Deng,Jing Liu,Shue Xiong,Junyi He,Xuemei Feng,Chunxia Guo,Weixian Wang,Gennadiy Zelinskyy,Gennadiy Zelinskyy,Mirko Trilling,Mirko Trilling,Kathrin Sutter,Kathrin Sutter,Tina Senff,Christopher Menne,Joerg Timm,Yanfang Zhang,Fei Deng,Yinping Lu,Jun Wu,Mengji Lu,Mengji Lu,Dongliang Yang,Ulf Dittmer,Ulf Dittmer,Baoju Wang,Xin Zheng +30 more
TL;DR: Wang et al. as discussed by the authors characterized the long-term impact of SARS-CoV-2 infection on the immune system and provided a comprehensive picture of cellular immunity of a convalescent COVID-19 patient cohort with the longest recovery time.
Journal ArticleDOI
COVID-19 : physiopathologie d’une maladie à plusieurs visages
TL;DR: The physiopathological mechanisms of each phase of COVID-19 - viral, immune and pro-thrombotic - notably because they involve different treatment are specified.
Journal ArticleDOI
Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteins.
Yang Li,Zhaowei Xu,Qing Lei,Dan-yun Lai,Hongyan Hou,He-wei Jiang,Yun-xiao Zheng,Xue-ning Wang,Jiaoxiang Wu,Ming-liang Ma,Bo Zhang,Hong Chen,Caizheng Yu,Jun-biao Xue,Hai-nan Zhang,Huan Qi,Shu-Juan Guo,Yandi Zhang,Xiaosong Lin,Zongjie Yao,Huiming Sheng,Ziyong Sun,Feng Wang,Xionglin Fan,Sheng-Ce Tao +24 more
TL;DR: The immunogenicity of the SARS-CoV-2 proteome is largely unknown, especially for non-structural proteins and accessory proteins as mentioned in this paper, where the authors collected 2,360 COVID-19 sera and 601 control sera.
Posted ContentDOI
SARS-CoV-2-specific IgA and limited inflammatory cytokines are present in the stool of select patients with acute COVID-19
Graham J. Britton,Alice Chen-Liaw,Francesca Cossarini,Alexandra E. Livanos,Matthew P. Spindler,Tamar Plitt,Joseph Eggers,Ilaria Mogno,Ana S. Gonzalez-Reiche,Sophia Siu,Michael Tankelevich,Lauren Tal Grinspan,Rebekah E. Dixon,Divya Jha,Adriana van de Guchte,Zenab Khan,Gustavo Martinez-Delgado,Fatima Amanat,Daisy A. Hoagland,Benjamin R. tenOever,Marla Dubinsky,Miriam Merad,Harm van Bakel,Florian Krammer,Gerold Bongers,Saurabh Mehandru,Jeremiah J. Faith +26 more
TL;DR: Although SARS-CoV-2 RNA was detectable in the stools of COVID-19 patients and select individuals had evidence for a specific mucosal IgA response, intestinal inflammation was limited, even in patients presenting with gastrointestinal symptoms.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
Journal ArticleDOI
COVID-19: consider cytokine storm syndromes and immunosuppression
Puja Mehta,Daniel F. McAuley,Michael Brown,Emilie Sanchez,Rachel Tattersall,Rachel Tattersall,Jessica J Manson +6 more
TL;DR: Re-analysis of data from a phase 3 randomised controlled trial of IL-1 blockade (anakinra) in sepsis, showed significant survival benefit in patients with hyperinflammation, without increased adverse events.
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