Immunology of COVID-19: Current State of the Science.
Nicolas Vabret,Graham J. Britton,Conor Gruber,Samarth Hegde,Joel Kim,Maria Kuksin,Rachel Levantovsky,Louise Malle,Alvaro Moreira,Matthew D. Park,Luisanna Pia,Emma Risson,Miriam Saffern,Bérengère Salomé,Myvizhi Esai Selvan,Matthew P. Spindler,Jessica Tan,Verena van der Heide,Jill Gregory,Konstantina Alexandropoulos,Nina Bhardwaj,Brian D. Brown,Benjamin Greenbaum,Zeynep H. Gümüş,Dirk Homann,Amir Horowitz,Alice O. Kamphorst,Maria A. Curotto de Lafaille,Saurabh Mehandru,Miriam Merad,Robert M. Samstein,Manasi Agrawal,Mark Aleynick,Meriem Belabed,Matthew Brown,Maria Casanova-Acebes,Jovani Catalan,Monica Centa,Andrew Charap,Andrew K Chan,Steven T. Chen,Jonathan Chung,Cansu Cimen Bozkus,Evan Cody,Francesca Cossarini,Erica Dalla,Nicolas F. Fernandez,John A. Grout,Dan Fu Ruan,Pauline Hamon,Etienne Humblin,Divya Jha,Julia Kodysh,Andrew Leader,Matthew Lin,Katherine E. Lindblad,Daniel Lozano-Ojalvo,Gabrielle Lubitz,Assaf Magen,Zafar Mahmood,Gustavo Martinez-Delgado,Jaime Mateus-Tique,Elliot Meritt,Chang Moon,Justine Noel,Timothy O'Donnell,Miyo Ota,Tamar Plitt,Venu Pothula,Jamie Redes,Ivan Reyes Torres,Mark P. Roberto,Alfonso R. Sanchez-Paulete,Joan Shang,Alessandra Soares Schanoski,Maria Suprun,Michelle Tran,Natalie Vaninov,C. Matthias Wilk,Julio A. Aguirre-Ghiso,Dusan Bogunovic,Judy H. Cho,Jeremiah J. Faith,Emilie K. Grasset,Peter S. Heeger,Ephraim Kenigsberg,Florian Krammer,Uri Laserson +87 more
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TLDR
The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.About:
This article is published in Immunity.The article was published on 2020-06-16 and is currently open access. It has received 1350 citations till now.read more
Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.
Chaolin Huang,Lixue Huang,Lixue Huang,Yeming Wang,Xia Li,Lili Ren,Xiaoying Gu,Xiaoying Gu,Liang Kang,Lili Guo,Min Liu,Xing Zhou,Jianfeng Luo,Zhenghui Huang,Shengjin Tu,Yue Zhao,Li Chen,Decui Xu,Yanping Li,Caihong Li,Lu Peng,Yong Mei Li,Wuxiang Xie,Dan Cui,Dan Cui,Lianhan Shang,Lianhan Shang,Guohui Fan,Guohui Fan,Jiuyang Xu,Geng Wang,Geng Wang,Ying Wang,Jingchuan Zhong,Chen Wang,Chen Wang,Jianwei Wang,Dingyu Zhang,Bin Cao +38 more
TL;DR: In this article, the authors describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.
Journal ArticleDOI
Coronavirus biology and replication: implications for SARS-CoV-2.
TL;DR: The first discoveries that shape the current understanding of SARS-CoV-2 infection throughout the intracellular viral life cycle are summarized and relate that to the knowledge of coronavirus biology.
Journal ArticleDOI
COVID-19 vaccine BNT162b1 elicits human antibody and T H 1 T cell responses.
Ugur Sahin,Alexander Muik,Evelyna Derhovanessian,Isabel Vogler,Lena M. Kranz,Mathias Vormehr,Alina Baum,Kristen E. Pascal,Jasmin Quandt,Daniel Maurus,Sebastian Brachtendorf,Verena Lörks,Julian Sikorski,Rolf Hilker,Dirk Becker,Ann Kathrin Eller,Jan Grützner,Carsten Boesler,Corinna Rosenbaum,Marie Cristine Kühnle,Ulrich Luxemburger,Alexandra Kemmer-Brück,David J. Langer,Martin Bexon,Stefanie Bolte,Katalin Karikó,Tania Palanche,Boris Fischer,Armin Schultz,Pei Yong Shi,Camila R. Fontes-Garfias,John L. Perez,Kena A. Swanson,Jakob Loschko,Ingrid L. Scully,Mark Cutler,Warren Kalina,Christos A. Kyratsous,David A. Cooper,Philip R. Dormitzer,Kathrin U. Jansen,Özlem Türeci +41 more
TL;DR: The robust RBD-specific antibody, T cell and favourable cytokine responses induced by the BNT162b1 mRNA vaccine suggest that it has the potential to protect against COVID-19 through multiple beneficial mechanisms.
Journal ArticleDOI
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.
Carolyn Rydyznski Moderbacher,Sydney I. Ramirez,Sydney I. Ramirez,Jennifer M. Dan,Jennifer M. Dan,Alba Grifoni,Kathryn M. Hastie,Daniela Weiskopf,Simon Bélanger,Robert K. Abbott,Christina K. Kim,Jinyong Choi,Yu Kato,Eleanor G. Crotty,Cheryl Kim,Stephen A. Rawlings,Jose Mateus,Longping V. Tse,April Frazier,Ralph S. Baric,Bjoern Peters,Jason A. Greenbaum,Erica Ollmann Saphire,Erica Ollmann Saphire,Davey M. Smith,Alessandro Sette,Alessandro Sette,Shane Crotty,Shane Crotty +28 more
TL;DR: A combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects suggested roles for both CD4 plus T cells in protective immunity in COVID-19.
References
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Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent
Eike J. Steinig,Sebastián Duchêne,D. Ashley Robinson,Stefan Monecke,Stefan Monecke,Maho Yokoyama,Maisem Laabei,Peter Slickers,Patiyan Andersson,Deborah A Williamson,Angela Kearns,Richard V. Goering,Elizabeth Dickson,Ralf Ehricht,Ralf Ehricht,Margaret Ip,Matthew V. N. O'Sullivan,Geoffrey W. Coombs,Andreas Petersen,Gráinne I. Brennan,Anna C. Shore,David C. Coleman,Annalisa Pantosti,Hermínia de Lencastre,Henrik Westh,Nobumichi Kobayashi,Helen Heffernan,Birgit Strommenger,Franziska Layer,Stefan Weber,Hege Vangstein Aamot,Leila Skakni,Sharon J. Peacock,Derek S. Sarovich,Simon R. Harris,Julian Parkhill,Ruth C. Massey,M. T. G. Holden,M. T. G. Holden,Stephen D. Bentley,Steven Y. C. Tong +40 more
TL;DR: The Bengal Bay clone emerged from a virulent progenitor circulating on the Indian subcontinent and subsequently global transmission was associated with travel or family contact in the region, demonstrating the importance of whole-genome sequencing for tracking the evolution of emerging and resistant pathogens.
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Chloroquine: Modes of action of an undervalued drug
TL;DR: Chloroquine has recently been tested as adjunct therapy in several inflammatory situations, such as rheumatoid arthritis and transplantation procedures, presenting intriguing and promising results.
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MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis
Vineet D. Menachery,Hugh D. Mitchell,Adam S. Cockrell,Lisa E. Gralinski,Boyd Yount,Rachel L. Graham,Eileen T. McAnarney,Madeline G. Douglas,Trevor Scobey,Anne Beall,Kenneth H. Dinnon,Jacob Kocher,Andrew E. Hale,Kelly G. Stratton,Katrina M. Waters,Ralph S. Baric +15 more
TL;DR: The absence of all four Middle East respiratory syndrome CoV accessory ORFs has major implications for viral replication and pathogenesis and disruption of accessory ORF functions in parallel may offer a rapid response platform to attenuation of future emergent strains based on both SARS- and MERS-CoV accessory OrF mutants.
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The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement
Brian D. Quinlan,Huihui Mou,Lizhou Zhang,Yan Guo,Wenhui He,Amrita Ojha,Mark S. Parcells,Guangxiang Luo,Wenhui Li,Guocai Zhong,Guocai Zhong,Hyeryun Choe,Michael Farzan +12 more
TL;DR: The data suggest that an RBD-based vaccine for SARS-CoV-2 could be safe and effective, and that anti-sera from immunized animals did not mediate antibody-dependent enhancement of S-protein-mediated entry under conditions in which Zika virus ADE was readily observed.
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Human-leukocyte antigen class I Cw 1502 and class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection.
Sheng-Fan Wang,Sheng-Fan Wang,Kuan Hsuan Chen,Marcelo Chen,Wen Yi Li,Yen Ju Chen,Ching Han Tsao,Muh Yong Yen,Jason C. Huang,Yi Ming Arthur Chen +9 more
TL;DR: A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).
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