Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
Citations
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Gut–microbiota–brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence
Xiayun Wan,Akifumi Eguchi,Youge Qu,Yong Yang,Lijia Chang,Jiajing Shan,Chisato Mori,Kenji Hashimoto +7 more
TL;DR: Gut microbiota may play a role in the microglial activation in the mPFC and NAc of adult mice after repeated WIN55,212–2 exposure during adolescence, and it is likely that gut–microbiota–microglia crosstalk might play a roles in increased risk for psychosis in adults with cannabis use during adolescence.
Journal ArticleDOI
Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain
Xingming Wang,Akifumi Eguchi,Yong Yang,Lijia Chang,Xiayun Wan,Jiajing Shan,Youge Qu,Li Ma,Chisato Mori,Jian-Jun Yang,Kenji Hashimoto +10 more
TL;DR: In this article , the authors investigated whether sub-diaphragmatic vagotomy (SDV) affects demyelination in CPZ-treated mice and found that SDV significantly ameliorated demyelin and microglial activation in the brain compared with sham-operated CPZ treated mice.
Journal ArticleDOI
Flaxseed Bioactive Compounds: Chemical Composition, Functional Properties, Food Applications and Health Benefits-Related Gut Microbes
TL;DR: The role of flaxseed substances in the maintenance of a healthy composition of the gut microbiome, prevention, and management of multiple diseases has recently been elucidated in various studies, which have highlighted its importance further as a powerful nutritional remedy as discussed by the authors .
Journal ArticleDOI
The association between dietary inflammatory index with sleep quality and obesity amongst iranian female students: A cross-sectional study.
Hadi Bazyar,Ahmad Zare Javid,Hossein Bavi Behbahani,Nitin Shivappa,James R. Hébert,Sara Khodaramhpour,Sara Khaje Zadeh,Vahideh Aghamohammadi +7 more
TL;DR: In this article, a cross-sectional study was conducted on 249 female college students to evaluate the relationship of the Association of Dietary Inflammatory Index (DII) with obesity and sleep quality among Iranian female students.
Journal ArticleDOI
Effects of partial- or whole-body exposures to 56Fe particles on brain function and cognitive performance in rats
Danielle S. Cahoon,Barbara Shukitt-Hale,Donna F. Bielinski,Elizabeth Hawkins,Alicia M. Cacioppo,Bernard M. Rabin +5 more
TL;DR: The results suggest that radiation to the body can impact the brain, therefore it may be necessary to re-evaluate the estimates of the risk of HZE particle-induced changes in neuronal function and cognitive performance.
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