Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
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The role of the intestine as a target with a therapeutic role in people with neurodegenerative diseases
TL;DR: The role of the gut microbiota and its therapeutic role in neurodegenerative diseases was discussed in this article , where the authors described the role of a set of microorganisms including common bacteria (Lactobacillus and S. aureus), fungi, and viruses.
Journal ArticleDOI
Tests for differential Gaussian Bayesian networks based on quadratic inference functions
Xianzheng Huang,Hongmei Zhang +1 more
TL;DR: Hypotheses testing procedures based on quadratic inference functions are proposed to test whether two Gaussian Bayesian networks are differential in structure, strength of associations between nodes, or both.
Book ChapterDOI
Microbiome influences on neuro-immune interactions in neurodegenerative disease.
TL;DR: A review of the literature related to Gut microbiome influences on neuro-immune interactions with a particular focus on neurological diseases is provided in this paper , where Gut microbiome-derived mediators, including short-chain fatty acids and other metabolites, lipopolysaccharide, and neurotransmitters, and their impact on neuro immune interactions as well as routes by which these interactions may occur are also discussed.
Journal ArticleDOI
Malnutrition and Fragility: From Children to Elderly with Probiotics
TL;DR: The risk of malnutrition coupled with the frailty syndrome, with a history of a poor microbiota during childhood, can make it difficult for the patient to recover and even lead to death, so the administration of probiotics can make the intervention timelier and avoid severe complications, even with a fatal outcome.
Journal ArticleDOI
Possible role of the <scp>NLRP3</scp> inflammasome and the gut–brain axis in multiple sclerosis‐related depression
TL;DR: In this paper , the authors discuss molecular mechanisms related to the GBA axis that can mediate dysbiosis, intestinal barrier dysfunction, disruption of blood-brain barrier integrity, neuroinflammation, and subsequent manifestation of MS-related major depressive disorder.
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