Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
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Product of metabolic activity of intestinal microbium trimethylamine-N-oxide (TMAO) — biomarker of progression of atherosclerosis-copy in the heart of the heart
TL;DR: Regulating the ratio of intestinal microorganisms or their ability to form a precursor of TMAO — TMA, may be a way to develop new tools for the prevention and treatment of atherosclerosis and prevent the progression of cardiovascular complications, including in patients with type 2 diabetes.
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State-of-the-Art Clinical Microbiology in South Korea: Current Trends and Future Prospects
Garima Sharma,Jin-Chul Kim +1 more
TL;DR: Researchers and clinicians have repeatedly explored the clinical aspects of microorganisms because the human body is inhabited by several different microbial species and their strains.
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Gut Microbiota: A Future Clinical Magic Bullet to Manifest Pathogenic Disease in the Current Future
TL;DR: In this paper , the authors discuss the impact of the human microbiome on health and their manifestation by focusing on vital mechanisms, and examine the current most relevant evidence concerning to antibiotics, probiotics, prebiotics, polyphenols, and fecal microbiota transplantation.
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Porphyromonas gingivalis-Derived Lipopolysaccharide Promotes Glioma Cell Proliferation and Migration via Activating Akt Signaling Pathways
TL;DR: Wang et al. as discussed by the authors found that exposure to 100 ng/mL P. gingivalis LPS induced a significant increase in the expression of TNF-α, TGF-β, MMP2, and MMP9.
A Perspective on Glyphosate Toxicity: The Expanding Prevalence of This Chemical Herbicide and Its Vast Impacts on Human and Animal Health
TL;DR: Glyphosate is a chemical compound initially patented as an herbicide in 1974 and sold as the main ingredient in herbicides under the trade name Roundup ® , with intended use for agriculture and farming as discussed by the authors .
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