Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
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Extra-cranial factors in the development of Alzheimer's disease.
Arnold R. Eiser,Tamas Fulop +1 more
TL;DR: Clinical research into the prevention of dementia needs to take this interplay of organ system dysfunction into account and the design of therapeutic interventions needs to address dysfunction in more than one system at a time.
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Distinctive Microbial Signatures and Gut-Brain Crosstalk in Pediatric Patients with Coeliac Disease and Type 1 Diabetes Mellitus.
Parul Singh,Parul Singh,Arun Rawat,Bara Al-Jarrah,Saras Saraswathi,Hoda Gad,Mamoun Elawad,Khalid Hussain,Mohammed A. Hendaus,Wesam Almasri,Rayaz A. Malik,Souhaila Al Khodor,Anthony K Akobeng,Anthony K Akobeng +13 more
TL;DR: It is concluded that disease-specific gut microbial features traceable down to the ASV level distinguish children with CD from T1DM and specific gut microbial signatures may be associated with small fiber neuropathy.
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Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders
TL;DR: In this article , the authors gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative and brain-related diseases, e.g., Alzheimer's and Parkinson's.
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The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer's Disease.
TL;DR: The role of oligomeric Ab and soluble hyperphosphorylated tau in the early pathogenesis of Alzheimer’s disease is provided and a new treatment strategy based on this is developed.
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Effects of Glyphosate and Roundup™ on the mammalian nervous system: A review.
TL;DR: Glyphosate is the active ingredient in glyphosate-based herbicides (GBHs) such as Roundup™, the most widely used herbicides in the world as mentioned in this paper , and GBHs are rated as Group 2A, probable human carcinogens, and also have documented effects on reproduction, acting as endocrine disruptive chemicals.
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