Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
Citations
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Identifying the culprits in neurological autoimmune diseases
TL;DR: A review of the most studied culprits as well as the mechanisms used by these to trigger NADs focuses on multiple sclerosis and Guillain-Barré syndrome.
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Long-term Outcomes of Stool Transplant in Alcohol-associated Hepatitis-Analysis of Clinical Outcomes, Relapse, Gut Microbiota and Comparisons with Standard Care.
TL;DR: The long-term outcomes of FMT and the gut microbiota (GM) changes in patients with severe alcohol-associated hepatitis (SAH), and alcohol use disorder are unknown as discussed by the authors .
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Impact of the mother's gut microbiota on infant microbiome and brain development
E. A. Mady,Ahmed S. Doghish,Walaa A. El-Dakroury,Samy Y. Elkhawaga,Ahmed Ismail,Hesham A. El-Mahdy,Elsayed G.E. Elsakka,H. M. El-Husseiny +7 more
TL;DR: In this paper , the authors examined the shaping of mother-to-infant microbial transmission, and explored possible paths for future research to advance our knowledge in this area, and provided information on early microbiota acquisition, future development, and prospective chances for intervention.
Journal ArticleDOI
The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders
Sankar Simla Praveenraj,S Sonali,Nikhilesh Anand,Hediyal Ahmed Tousif,C. Vichitra,Manjunath Kalyan,Perumalswamy Velumani Kanna,Kumar A Chandana,Paneyala Shasthara,Arehally M. Mahalakshmi,Jiang Yang,Seithikurippu R. Pandi-Perumal,Meena Kishore Sakharkar,Saravana Babu Chidambaram +13 more
TL;DR: Data suggests that TMAO levels increase with age-related cognitive dysfunction and also induce mitochondrial dysfunction, oxidative stress, neuronal senescence, and synaptic damage in the brain, which could provide novel therapeutic options for neurological illnesses.
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Chaihu-Shugan-San (Shihosogansan) alleviates restraint stress-generated anxiety and depression in mice by regulating NF-κB-mediated BDNF expression through the modulation of gut microbiota
TL;DR: In this paper, a Chinese traditional medicine called Chaihu-shugan-san (CSS) was used to treat anxiety and depression in mice. But, the effect of CSS on the effect on depression and gut dysbiosis in mice was not analyzed.
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