Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
Citations
More filters
Journal ArticleDOI
Toxicity of Microplastics and Nanoplastics in Mammalian Systems
TL;DR: The prevailing data suggest that micro- and nanoplastic accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences, and there is a need for cellular and systemic toxicity due to micro-and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.
Journal ArticleDOI
The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology.
TL;DR: The status of the knowledge and the open questions in the field focusing on the function of intestinal microbial metabolites or products on CNS cells during healthy and inflammatory conditions, such as multiple sclerosis, Alzheimer's and Parkinson’s diseases, and also neuropsychiatric disorders are discussed.
Journal ArticleDOI
Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease.
TL;DR: As aging together with poor diet and gut-derived inflammatory response due to dysbiosis contributes to the pathogenesis of AD, modification of gut microbial composition by uptake of probiotic-rich food can act as a preventive/therapeutic option for AD.
Journal ArticleDOI
Current and Future Trends on Diagnosis and Prognosis of Glioblastoma: From Molecular Biology to Proteomics.
Artemiy S. Silantyev,Luca Falzone,Massimo Libra,Olga I. Gurina,Karina Sh Kardashova,Taxiarchis Konstantinos Nikolouzakis,Alexander E. Nosyrev,Chris W. Sutton,Panayiotis D. Mitsias,Aristides M. Tsatsakis +9 more
TL;DR: Both benefits and pitfalls of molecular biology and proteomics analyses are discussed, including the different mass spectrometry-based analytical techniques, highlighting how these investigation strategies are powerful tools to study the biology of glioblastoma, as well as to develop advanced methods for the management of this pathology.
Journal ArticleDOI
Gut microbial molecules in behavioural and neurodegenerative conditions.
TL;DR: Bacterial metabolites with known or suspected neuromodulatory activity are described, mechanisms of signalling pathways from the gut microbiota to the brain are defined and direct effects that gut bacterial molecules are likely exerting on specific brain cells are discussed.
References
More filters
Journal ArticleDOI
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Timothy G. Dinan,John F. Cryan +1 more
TL;DR: There is a growing realisation that the gut–brain axis and its regulation by the microbiota may play a key role in the biological and physiological basis of neurodevelopmental, age‐related and neurodegenerative disorders, and it is plausible that such neuropsychiatric disorders might be treated by targeting the microbiota either by microbiota transplantation, antibiotics or psychobiotics.
Journal ArticleDOI
The importance of neuritic plaques and tangles to the development and evolution of AD.
TL;DR: The significant increase in neuritic plaques, but not neurofibrillary tangles, in patients with even mild Alzheimer disease at death compared with normal control subjects suggests that only neuritic Plaques are associated with the earliest symptoms of Alzheimer disease.
Journal ArticleDOI
A gut-brain neural circuit for nutrient sensory transduction
Melanie Maya Kaelberer,Kelly L. Buchanan,Marguerita E. Klein,Bradley B. Barth,Marcia Montoya,Xiling Shen,Diego V. Bohórquez +6 more
TL;DR: It is found that, in addition to the well-described classical paracrine transduction, enteroendocrine cells also form fast, excitatory synapses with vagal afferents (see the Perspective by Hoffman and Lumpkin), this more direct circuit for gut-brain signaling uses glutamate as a neurotransmitter.
Journal ArticleDOI
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 + T cells via TLR4 signaling
Chrystal M. Paulos,Claudia Wrzesinski,Andrew Kaiser,Christian S. Hinrichs,Marcello Chieppa,Lydie Cassard,Douglas C. Palmer,Andrea Boni,Pawel Muranski,Zhiya Yu,Luca Gattinoni,Paul A. Antony,Steven A. Rosenberg,Nicholas P. Restifo +13 more
TL;DR: Disruption of the homeostatic balance between the host and microbes can enhance cell-based tumor immunotherapy, leading to long-term cure of mice with large B16F10 tumors and enhanced autoimmune vitiligo.
Journal ArticleDOI
Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation
TL;DR: A mounting body of evidence indicates that the microbial metabolites short-chain fatty acids (SCFAs) have profound effects on T cells and directly and indirectly regulate their differentiation.
Related Papers (5)
Host microbiota constantly control maturation and function of microglia in the CNS
Daniel Erny,Anna Lena Hrabě de Angelis,Diego Jaitin,Peter Wieghofer,Ori Staszewski,Eyal David,Hadas Keren-Shaul,Tanel Mahlakõiv,Kristin Jakobshagen,Thorsten Buch,Vera Schwierzeck,Olaf Utermöhlen,Eunyoung Chun,Wendy S. Garrett,Kathy D. McCoy,Andreas Diefenbach,Peter Staeheli,Bärbel Stecher,Ido Amit,Marco Prinz +19 more
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
John F. Cryan,Timothy G. Dinan +1 more