Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
Citations
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The gut microbiome variability of a butterflyfish increases on severely degraded Caribbean reefs
F. K. Clever,Jade M. Sourisse,Richard F. Preziosi,Jonathan A. Eisen,Elena Guerra,Jarrod J. Scott,Laetitia G. E. Wilkins,Andrew H. Altieri,W. Owen McMillan,Matthieu Leray +9 more
TL;DR: This paper found significant differences in the gut microbiome composition of a facultative coral-feeding butterflyfish ( Chaetodon capistratus) across Caribbean reefs that differ markedly in live coral cover (∼0-30%).
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Gut microbiota in forty cases of egyptian relapsing remitting multiple sclerosis
Sherein G. Elgendy,Rawan Abd-Elhameed,Enas A. Daef,Shereen M. Mohammed,Hebatallah M. Hassan,Mohamed A El-Mokhtar,Ahmed Nasreldein,Eman M. Khedr +7 more
TL;DR: The changes in gut microbiota are associated with exacerbation of MS disease, resulting in the depletion or enrichment of certain bacteria that may affect the immune balance leading to predisposition to MS.
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The importance of gut-brain axis and use of probiotics as a treatment strategy for multiple sclerosis
TL;DR: A review of recent research on the function of gut microbiota in the onset of MS and how probiotics have a substantial impact on gastrointestinal disruption in MS and other neuro disorders can be found in this article .
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The Vascular-Immune Hypothesis of Alzheimer’s Disease
Rashi I. Mehta,Rupal I. Mehta +1 more
TL;DR: A review of the literature with regard to neuropathologic criteria and incipient Alzheimer's disease changes, and converging concepts regarding vascular and immune factors in AD are discussed in this paper .
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