Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
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Human mini-blood–brain barrier models for biomedical neuroscience research: a review
TL;DR: In this paper , the authors provide insight into the development and deployment of in vitro human blood-brain barrier (BBB) models that allow investigation of the physiology and pathology of neurological therapeutic avenues.
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Gut microbiome and neurosurgery: Implications for treatment
Jonathan Willman,Matthew Willman,Ramya Reddy,Anna Maria Fusco,Sai Sriram,Yusuf Mehkri,J. Charles,Joel Goeckeritz,Brandon Lucke-Wold +8 more
TL;DR: The current understanding of the key protective and deleterious roles the gut microbiome plays in the pathogenesis of several common neurosurgical concerns is presented and the link appears to be bidirectional as gut dysbiosis contributes to secondary CNS injury in each of these ailment settings.
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Optimization control method for industrial Internet of Things based on biological adaptive coevolutionary
TL;DR: In this paper, an adaptive evolutionary based on biological cooperation (BCAE) algorithm is proposed to solve the dynamic multi-objective optimization problem of Industrial Internet of Things (IIoT) services to reduce the total service cost and service time.
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OUP accepted manuscript
TL;DR: In this article , the effect of diet on gut microbiota is highlighted, along with the possibility of probiotic bacteria as psychobiotics in the treatment or prevention of mental health-related disorders.
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Pancreatic dysfunction and duodenal inflammatory responses coordinate with refractory epigastric pain including functional dyspepsia "A narrative review".
Seiji Futagami,Mako Wakabayashi +1 more
TL;DR: How duodenal inflammation may play a role in the etiology of FD is reviewed and whether pancreatic dysfunction may be associated with FD through intestinal inflammation is demonstrated.
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