Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
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Specificity of gut microbiota in children with autism spectrum disorder in Slovakia and its correlation with astrocytes activity marker and specific behavioural patterns.
Aleksandra Tomova,Katarína Šoltys,Gabriela Repiská,Lenka Pálková,D. Filcikova,Gabriel Minarik,Jan Turna,K. Prochotska,Katarina Babinska,Daniela Ostatníková +9 more
TL;DR: Distinct faecal microbiota in children with ASD was found to be more heterogeneous compared to that in neurotypical children and different bacterial abundance and correlation with behavioural and GI manifestations revealed several bacterial genera possibly important for ASD.
Journal ArticleDOI
Postbiotics as potential new therapeutic agents for metabolic disorders management.
TL;DR: In this paper , a review of the benefits of postbiotic derivatives for metabolic disorders and related alterations is presented, including anti-inflammatory, antibacterial, immunomodulatory, anti-carcinogenic, antioxidant, antihypertensive, antiproliferative, and hypocholesterolaemia properties.
Journal ArticleDOI
The dichotomous role of the gut microbiome in exacerbating and ameliorating neurodegenerative disorders.
TL;DR: Polyphenol prebiotics delivered in combination with probiotics (synbiotics) present an exciting new avenue to harness the microbiome to attenuate immune inflammatory responses which ultimately may influence brain cascades associated with promotion of neurodegeneration across the lifespan.
Journal ArticleDOI
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
Rosalía Fernández-Calle,s. Konings,Javier Frontiñán-Rubio,Juan García-Revilla,Lluís Camprubí-Ferrer,Martina Svensson,Isak Martinson,Antonio Boza-Serrano,José L. Venero,Henrietta M. Nielsen,Gunnar K. Gouras,Tomas Deierborg +11 more
TL;DR: In this article , a comprehensive review of the APOE genotype up to date and its implications on AD and CNS pathologies is presented, including the effect of APOE polymorphisms on astrocytic and microglial function, synaptic function, amyloid-β load, tau pathology, autophagy, and cell-cell communication.
Journal ArticleDOI
Betaine supplementation is associated with the resilience in mice after chronic social defeat stress: a role of brain-gut-microbiota axis
Youge Qu,Kai Zhang,Yaoyu Pu,Lijia Chang,Siming Wang,Yunfei Tan,Xingming Wang,Jiancheng Zhang,Tetsuo Ohnishi,Takeo Yoshikawa,Kenji Hashimoto +10 more
TL;DR: Betaine supplementation contributed to resilience to anhedonia in mice subjected to CSDS through anti-inflammation action, suggesting that betaine could be a prophylactic nutrient to prevent stress-related psychiatric disorders.
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