Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
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Towards early detection of neurodegenerative diseases: A gut feeling
TL;DR: A review of the leading players of the so-called diet-microbiota-gut-brain (DMGB) axis in the context of neurodegenerative diseases can be found in this paper .
Journal ArticleDOI
High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies
TL;DR: In this paper , the effects of high-fat diet on the E. coli overgrowth were found to be reduced by CBD and Omega 3, and the memory impairment and anxiety induction by HFD was also significantly ameliorated.
Journal ArticleDOI
Microbiomics in Collusion with the Nervous System in Carcinogenesis: Diagnosis, Pathogenesis and Treatment
Rodney Hull,Georgios Lolas,Georgios Lolas,Stylianos Makrogkikas,Lasse Jensen,Konstantinos N. Syrigos,George Evangelou,Llewellyn Padayachy,Cyril Egbor,Ravi Mehrotra,Tshepiso Jan Makhafola,Tshepiso Jan Makhafola,Meryl Oyomno,Zodwa Dlamini +13 more
TL;DR: In this article, the authors discuss the latest evidence that support the importance of microbiota and peripheral nerves in cancer development and dissemination, and discuss how these factors affect the development and progression of cancer in a similar manner as the blood and lymphatic systems.
Journal ArticleDOI
Effects of the antibiotic rifaximin on cortical functional connectivity are mediated through insular cortex.
Davide Sometti,Davide Sometti,Chiara Ballan,Chiara Ballan,Huiying Wang,Christoph Braun,Paul Enck +6 more
TL;DR: In this paper, the effects of 7 days intake of Rifaximin (non-absorbable antibiotic) on functional brain connectivity using magnetoencephalography were investigated in a randomized, double-blind, placebo-controlled study.
Journal ArticleDOI
Differences in the gut microbiome composition of Korean children and adult samples based on different DNA isolation kits
TL;DR: A 16S rRNA amplicon sequencing on 78 Korean samples composed of adults, children, normal and obese groups found that Ct bio (Ct) kit recovered higher DNA yields and OTUs than QIAamp® PowerFecal® DNA Kit (Qia), and there was a difference in the intestinal flora between healthy Korean adults and children.
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