Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
Citations
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The gut microbiota-neuroimmune crosstalk and neuropathic pain: a scoping review
TL;DR: In this paper , the authors conducted a systematic scoping review to examine the gut microbial-neuroimmune connection to neuropathic pain and the potential therapeutic targets and found that the gut flora plays a role in the immunological, neurological, and metabolic signalling pathways associated with NP and suggested that an imbalanced-gut microbiome and subsequent activation of biochemical and neuro-immunologic pathways may influence the development of NP.
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The Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota
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Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases
Hohyeon Han,Jinah Jang +1 more
TL;DR: This review outlines state-of-the-art biofabrication technologies for modeling in vitro human intestines and deliberate future research directions to develop more functional in vitro intestinal models to study the gut–brain axis in neurological diseases rather than simply recreating the morphology.
Peer Review
Patho-mechanisms in the gut microbiota implicated in the immunological neuroendocrine gut-brain pathway
Monika S. Deore,Saba Naqvi +1 more
TL;DR: In this article , the Gut-brain axis has been studied and the current state of knowledge of microbial ecology homeostasis and dysbiosis in the human gut, as well as health complications linked to microbiome dysbiotic configuration.
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