Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.
Qianquan Ma,Qianquan Ma,Changsheng Xing,Wenyong Long,Helen Yicheng Wang,Qing Liu,Rongfu Wang,Rongfu Wang,Rongfu Wang +8 more
TLDR
The biological interplay between gut-brain axis is discussed, and how this communication may be dysregulated in neurological diseases is explored, and new insights in modification of gut microbiota composition are highlighted.Abstract:
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. Further, we highlight new insights in modification of gut microbiota composition, which may emerge as a promising therapeutic approach to treat CNS disorders.read more
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Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model
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TL;DR: This paper conducted a comprehensive review of the existing literature in order to: a) synthesize current knowledge on fibromyalgia; b) explore and highlight multi-level links and pathways between different systems; and c) build bridges connecting disparate perspectives.
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The human gut virome: composition, colonization, interactions, and impacts on human health
Evan Pargin,Michael J. Roach,Amber D. Skye,Bhavya Papudeshi,Laura K Inglis,Vijini Mallawaarachchi,Susanna R. Grigson,Robert Alonzo Edwards,Sarah K. Giles +8 more
TL;DR: A review of the literature surrounding the Gut virome, its establishment, its impact on human health, the methods used to investigate it, and the viral dark matter veiling our understanding of the gut virome can be found in this article .
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Can the Gut Microbiota Serve as a Guide to the Diagnosis and Treatment of Childhood Epilepsy?
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The role of microbiota-gut-brain axis in neurodegenerative diseases: biochemical and therapeutic aspects
Januário Tomás Ernesto,Caio Miranda Damasio,Vanessa Silva Gontijo,Juciano Gasparotto,C. Viegas Jr. +4 more
TL;DR: In this article , the authors present the most recent data from the scientific literature associated with the physiological, biochemical and cellular aspects involved in the interrelationship between the gut-brain axis and NDs, discussing the role of the intestinal microbiota, and its relationship with CNS disorders.
References
More filters
Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal ArticleDOI
Alzheimer's disease: the amyloid cascade hypothesis
John Hardy,Gerald A. Higgins +1 more
TL;DR: An extensive catalog of genes that act in a migrating cell is provided, unique molecular functions involved in nematode cell migration are identified, and similar functions in humans are suggested.
Journal ArticleDOI
2016 Alzheimer's disease facts and figures
Journal ArticleDOI
Astrocytes: biology and pathology
TL;DR: Astrocyte functions in healthy CNS, mechanisms and functions of reactive astrogliosis and glial scar formation, and ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions are reviewed.
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