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Journal ArticleDOI

Improving human forensics through advances in genetics, genomics and molecular biology

TLDR
Advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future, including new molecular approaches for finding individuals previously unknown to investigators, and new molecular methods to support links between forensic sample donors and criminal acts.
Abstract
Forensic DNA profiling currently allows the identification of persons already known to investigating authorities. Recent advances have produced new types of genetic markers with the potential to overcome some important limitations of current DNA profiling methods. Moreover, other developments are enabling completely new kinds of forensically relevant information to be extracted from biological samples. These include new molecular approaches for finding individuals previously unknown to investigators, and new molecular methods to support links between forensic sample donors and criminal acts. Such advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future.

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Citations
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Hundreds of variants clustered in genomic loci and biological pathways affect human height

Hana Lango Allen, +289 more
TL;DR: In this paper, the authors show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait, revealing patterns with important implications for genetic studies of common human diseases and traits.
Journal ArticleDOI

Routes for breaching and protecting genetic privacy.

TL;DR: An overview of genetic privacy breaching strategies is presented, outlining the principles of each technique, the underlying assumptions, and their technological complexity and maturation, as well as highlighting different cases that are relevant to genetic applications.
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The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA

TL;DR: The HIrisPlex system introduced here, including a single multiplex test assay, an interactive tool and prediction guide, and recommendations for reporting final outcomes, represents the first tool for simultaneously establishing categorical eye and hair colour of a person from DNA.
Journal ArticleDOI

lobSTR: A short tandem repeat profiler for personal genomes.

TL;DR: The speed and reliability of lobSTR exceed the performance of current mainstream algorithms for STR profiling, and the algorithm was used to conduct a comprehensive survey of STR variations in a deeply sequenced personal genome.
Journal ArticleDOI

Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk

Bernard Lo
- 24 Feb 2015 - 
TL;DR: It is concluded that sharing data is in the public interest, but a multi-stakeholder effort is needed to develop a culture, infrastructure, and policies that will foster responsible sharing—now and in the future.
References
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Journal ArticleDOI

Inference of population structure using multilocus genotype data

TL;DR: Pritch et al. as discussed by the authors proposed a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations, which can be applied to most of the commonly used genetic markers, provided that they are not closely linked.
Journal ArticleDOI

Fast model-based estimation of ancestry in unrelated individuals

TL;DR: The results show that ADMIXTURE's computational speed opens up the possibility of using a much larger set of markers in model-based ancestry estimation and that its estimates are suitable for use in correcting for population stratification in association studies.
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Population structure and eigenanalysis

TL;DR: An approach to studying population structure (principal components analysis) is discussed that was first applied to genetic data by Cavalli-Sforza and colleagues, and results from modern statistics are used to develop formal significance tests for population differentiation.
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Worldwide human relationships inferred from genome-wide patterns of variation.

TL;DR: A pattern of ancestral allele frequency distributions that reflects variation in population dynamics among geographic regions is observed and is consistent with the hypothesis of a serial founder effect with a single origin in sub-Saharan Africa.
Journal ArticleDOI

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Hana Lango Allen, +344 more
- 14 Oct 2010 - 
TL;DR: It is shown that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait, and indicates that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
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