Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
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Book ChapterDOI
The Humoral Immune Response to T Cell–Independent Antigens
TL;DR: Although antibody responses to TI antigens do not require T cell help, T cells can play a major role in augmenting these responses, especially when the TI antigen is expressed by an intact pathogen.
Journal ArticleDOI
Gram-positive bacteria: a major microbial ‘turn-on’ for invariant NKT cells.
R.C.G. de Bruin,Famke L. Schneiders,Saskia J. A. M. Santegoets,H.M.W. Verheul,T.D. de Gruijl,J.J. (Hans) van der Vliet +5 more
TL;DR: Kinjo et al. as mentioned in this paper found that the unique hydrophobic lipid chains of S. pneumoniae antigens contribute to the iTCR epitope (and iNKT activation) by defining the exposed sugar.
Dissertation
Invariant NKT cells and CD1d in HIV-1 infection
TL;DR: The Vpu protein of HIV-1 may play a significant role in evasion from CD1d-specific immune responses, and this thesis demonstrates NKG2D-dependent iNKT cell activation, which supports the notion that iN KT cells play an important role in the host defence against HIV- 1.
Journal ArticleDOI
Lipid-Reactive T Cells in Immunological Disorders of the Lung.
TL;DR: Current understanding of the biology of CD1-reactive T cells with a specific focus on their roles in several pulmonary disorders is discussed.
Journal ArticleDOI
iNKT cells participate in the exacerbation of systemic candidal infection
Norihito Tarumoto,Yuki Kinjo,Naoki Kitano,Kazutoshi Shibuya,Shigefumi Maesaki,Yoshitsugu Miyazaki +5 more
TL;DR: The results suggest that the excessive IFNγ released from candida and bacterial co-infection is a critical factor in worsening candidal infection.
References
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Journal ArticleDOI
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Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Yuki Kinjo,Emmanuel Tupin,Douglass Wu,Masakazu Fujio,Raquel Garcia-Navarro,Mohammed Rafii El Idrissi Benhnia,Mohammed Rafii El Idrissi Benhnia,Dirk M. Zajonc,Dirk M. Zajonc,Gil Ben-Menachem,Gary D. Ainge,Gavin F. Painter,Archana Khurana,Kasper Hoebe,Samuel M. Behar,Bruce Beutler,Ian A. Wilson,Moriya Tsuji,Timothy J. Sellati,Chi-Huey Wong,Mitchell Kronenberg +20 more