Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
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Exacerbation of Invasive Candida albicans Infection by Commensal Bacteria or a Glycolipid Through IFN-γ Produced in Part by iNKT Cells
Norihito Tarumoto,Yuki Kinjo,Naoki Kitano,Daisuke Sasai,Keigo Ueno,Akiko Okawara,Yuina Izawa,Yuina Izawa,Minoru Shinozaki,Hiroshi Watarai,Masaru Taniguchi,Haruko Takeyama,Shigefumi Maesaki,Kazutoshi Shibuya,Yoshitsugu Miyazaki +14 more
TL;DR: In this paper, the effect of glycolipid antigen-dependent iNKT cell activation on the clearance of C. albicans infection was investigated, and the survival rate, fungal burden, and cytokine production were analyzed.
Journal ArticleDOI
Stages versus subsets: Invariant Natural Killer T cell lineage differentiation.
TL;DR: The molecules regulating the differentiation of iNKT cell lineages, the transcription factors associated with their development, and the role of E protein transcription factors and their negative regulators the Id proteins are discussed, as these cells develop from immature progenitor cells to terminally differentiated cells in peripheral tissue.
glycolipid through IFNγ produced in part by iNKT cells
Norihito Tarumoto,Yuki Kinjo,Naoki Kitano,Daisuke Sasai,Keigo Ueno,Yuina Izawa,Minoru Shinozaki,Hiroshi Watarai,Masaru Taniguchi,Haruko Takeyama,Shigefumi Maesaki,Kazutoshi Shibuya,Yoshitsugu Miyazaki +12 more
TL;DR: The results indicate that coinfecting commensal bacteria exacerbate C. albicans infection through IFN-γ produced, in part, by iNKT cells, which is a major cause of invasive fungal infections.
Journal ArticleDOI
The role of invariant NKT cells in organ-specific autoimmunity.
Di Pietro C,Falcone M +1 more
TL;DR: The possible mechanism of action and final effect of the different iNKT cell subsets in the pathogenesis of T cell-mediated autoimmune diseases are reviewed and the role of NKT17 cells is raised.
Journal ArticleDOI
Activation of invariant natural killer T cells stimulated with microbial α-mannosyl glycolipids
Michio Shimamura,Masaki Yamamura,Tatsuya Nabeshima,Naoki Kitano,Peter van den Elzen,Hasan Yesilkaya,Peter W. Andrew,Petr A. Illarionov +7 more
TL;DR: These results suggest that these microbial α-mannosyl glycolipids are capable of being recognized by both the invariant TCR and PRRs and inducing immune responses.
References
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