Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
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Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections.
TL;DR: The current knowledge into the biology of these cells during lung (viral and bacterial) infections including activation mechanisms and functions are discussed and future strategies targeting these cell types to optimize immune responses against respiratory pathogens are discussed.
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Nod1 and Nod2 Enhance TLR-Mediated Invariant NKT Cell Activation during Bacterial Infection
Thirumahal Selvanantham,Nichole K. Escalante,Mayra Cruz Tleugabulova,Stephanie Fieve,Stephen E. Girardin,Dana J. Philpott,Thierry Mallevaey +6 more
TL;DR: It is shown that the cytosolic peptidoglycan-sensing receptors Nod1 and Nod2 are necessary for optimal IFN-γ production by iNKT cells, as well as NK cells, and suggest that multiple innate pathways can cooperate to regulate iN KT cell activation during bacterial infection.
Journal ArticleDOI
Enterogenous bacterial glycolipids are required for the generation of natural killer T cells mediated liver injury
Yingfeng Wei,Benhua Zeng,Jianing Chen,Guangying Cui,Chong Lu,Wei Wu,Jiezuan Yang,Hong Wei,Rufeng Xue,Li Bai,Zhi Chen,Lanjuan Li,Kazuya Iwabuchi,Toshimitsu Uede,Luc Van Kaer,Hongyan Diao +15 more
TL;DR: It is suggested that glycolipid antigens derived from intestinal commensal bacteria are important hepatic NKT cell agonist and these antigen are required for the activation of NKT cells during ConA-induced liver injury.
Journal ArticleDOI
NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology
J. Christoph Vahl,Klaus Heger,Nathalie Knies,Marco Y. Hein,Louis Boon,Hideo Yagita,Bojan Polić,Marc Schmidt-Supprian +7 more
TL;DR: It is proposed that peripheral NKT cells become unresponsive to and thus are independent of their autoreactive TCR, and therefore not affected by induced TCR ablation.
Journal ArticleDOI
Targeting Innate-Like T Cells in Tuberculosis
TL;DR: Through rapid cytokine secretion, innate-like T cells function in early defense and memory response, offering novel advantages over conventional T cells in the design of anti-tuberculosis strategies.
References
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