Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
Citations
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production against blood group A carbohydrates Blockade of invariant TCR-CD1d interaction specifically inhibits antibody
TL;DR: It is demonstrated that CD1d-restricted natural killer T (NKT) cells are required to produce anti-A antibodies (Abs), probably through collaboration with B-1a cells, and IL-5 secreted from NKT cells critically regulatesAnti-A Ab production by B- 1a cells.
Book ChapterDOI
The Role of Invariant NKT Cells in Immunity
TL;DR: Clinical observations in conjunction with insights from preclinical work highlight their importance in the alloresponse associated with hematopoietic stem cell transplantation and provide the impetus for exploring the therapeutic potential of iNKT cells.
Journal ArticleDOI
Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells.
Samanta Melgar-Rodríguez,Emilio A Cafferata,Emilio A Cafferata,Nicolás Díaz,Miguel A. Peña,Luis González-Osuna,Carolina Rojas,Alfredo Sierra-Cristancho,Alfredo Sierra-Cristancho,Angélica M. Cárdenas,Angélica M. Cárdenas,Jaime Díaz-Zúñiga,Rolando Vernal +12 more
TL;DR: In this article, the potential regulatory role of the IL-10-producing natural killer T (NKT10) cells was analyzed. But the authors did not consider the role of NKT10 cells in the pathogenesis of periodontitis.
Journal ArticleDOI
Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors
Emilie Barsac,Carolina de Amat Herbozo,Loïc Gonzalez,Thomas Baranek,Thierry Mallevaey,Christophe Paget +5 more
TL;DR: In this article, the authors review the current understanding of the functions and regulatory mechanisms of protumoral unconventional T cell subsets in the tumor environment and discuss the therapeutic potential of these deleterious subsets.
Posted ContentDOI
Specialized subsets of innate-like T cells and dendritic cells protect from lethal pneumococcal infection in the lung
Mallory Paynich Murray,Catherine M. Crosby,Catherine M. Crosby,Paola Marie Marcovecchio,Paola Marie Marcovecchio,Nadine Hartmann,Shilpi Chandra,Meng Zhao,Meng Zhao,Meng Zhao,Archana Khurana,Sonja P. Zahner,Sonja P. Zahner,Björn E. Clausen,Fadie T. Coleman,Joseph P. Mizgerd,Zbigniew Mikulski,Mitchell Kronenberg,Mitchell Kronenberg +18 more
TL;DR: Innate-like T cells, including invariant natural killer T (iNKT) cells, mucosal-associated invariant T (MAIT) cells and {gamma-delta} T cells are present in various barrier tissues, including the lung.
References
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Journal Article
Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC.
TL;DR: Although universal screening for GBS colonization is anticipated to result in further reductions in the burden of GBS disease, the need to monitor for potential adverse consequences of intrapartum antibiotic use, such as emergence of bacterial antimicrobial resistance or increased incidence or severity of non-GBS neonatal pathogens, continues.
Journal ArticleDOI
Innate Immunity: The Virtues of a Nonclonal System of Recognition
TL;DR: Characterization of the nonclonal receptors of the innate immune system responsible for the adjuvant activity, and, evidently, for the associated side effects, would provide a powerful alternative approach, which would ultimately allow one to target these receptors directly.
Journal ArticleDOI
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.
Tetsu Kawano,Junqing Cui,Yasuhiko Koezuka,Isao Toura,Yoshikatsu Kaneko,Kazuhiro Motoki,Hitomi Ueno,Ryusuke Nakagawa,Hiroshi Sato,Eisuke Kondo,Haruhiko Koseki,Masaru Taniguchi +11 more
TL;DR: Glycosylceramide-mediated proliferative responses of Valpha14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein.
Journal ArticleDOI
The global burden of group A streptococcal diseases
TL;DR: The need to reinforce current control strategies, develop new primary prevention strategies, and collect better data from developing countries for most diseases is highlighted, as GAS is an important cause of morbidity and mortality.
Journal ArticleDOI
Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates
Katherine L. O'Brien,Lara J. Wolfson,James P. Watt,Emily Henkle,Maria Deloria-Knoll,Natalie McCall,Ellen Lee,Kim Mulholland,Orin S. Levine,Thomas Cherian +9 more
TL;DR: The burden of pneumococcal pneumonia is measured by applying the proportion of pneumonia cases caused by S pneumoniae derived from efficacy estimates from vaccine trials to WHO country-specific estimates of all-cause pneumonia cases and deaths, using disease incidence and case-fatality data from a systematic literature review.
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Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Yuki Kinjo,Emmanuel Tupin,Douglass Wu,Masakazu Fujio,Raquel Garcia-Navarro,Mohammed Rafii El Idrissi Benhnia,Mohammed Rafii El Idrissi Benhnia,Dirk M. Zajonc,Dirk M. Zajonc,Gil Ben-Menachem,Gary D. Ainge,Gavin F. Painter,Archana Khurana,Kasper Hoebe,Samuel M. Behar,Bruce Beutler,Ian A. Wilson,Moriya Tsuji,Timothy J. Sellati,Chi-Huey Wong,Mitchell Kronenberg +20 more