Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
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Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells.
Natsuo Yamamoto,Natsuo Yamamoto,Steven M. Kerfoot,Andrew T. Hutchinson,Charles S. Dela Cruz,Naomi Nakazawa,Marian Szczepanik,Marian Szczepanik,Monika Majewska-Szczepanik,Monika Majewska-Szczepanik,Katarzyna Nazimek,Katarzyna Nazimek,Noboru Ohana,Krzysztof Bryniarski,Krzysztof Bryniarski,Tsutomu Mori,Masamichi Muramatsu,Keiji Kanemitsu,Philip W. Askenase +18 more
TL;DR: This study is the first to demonstrate the importance of AID in generating an appropriate B1a cell response to pathogenic bacteria, and shows that natural IgM produced by conventional B 1a cells are not responsible for pneumonia clearance compared with the AID‐dependent subset.
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Evolution of nonclassical MHC-dependent invariant T cells
TL;DR: The current understanding of a nonclassical MHC class I-restricted iT cell population in the amphibian Xenopus laevis is reviewed, with parallels with the mammalian iNKT and MAIT cells underline the crucial biological roles of these evolutionarily ancient immune subsets.
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Aberrant presentation of self-lipids by autoimmune B cells depletes peripheral iNKT cells
Andy Hee-Meng Tan,William P. K. Chong,Sze-Wai Ng,Nurhidayah Basri,Shengli Xu,Shengli Xu,Kong-Peng Lam +6 more
TL;DR: Findings unveil a critical link between autoimmunity, B cell lipidome, and the maintenance of peripheral iNKT cells and highlight an essential homeostatic function of B cells beyond antibody production.
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Group B Streptococcus Induces a Robust IFN-γ Response by CD4(+) T Cells in an In Vitro and In Vivo Model.
Damian Clarke,Corinne Letendre,Marie-Pier Lecours,Paul Lemire,Tristan Galbas,Jacques Thibodeau,Mariela Segura +6 more
TL;DR: In this article, the authors evaluated CD4+ T cell activation profiles in response to Group B Streptococcus (GBS) serotype III infection through in vivo, ex vivo, and in vitro approaches.
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From Lysosomal Storage Diseases to NKT Cell Activation and Back
TL;DR: The current knowledge about NKT cells in the context of LSDs is reviewed, including the alterations detected, the proposed mechanisms to explain these defects, and the relevance of these findings for disease pathology.
References
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Journal ArticleDOI
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Tetsu Kawano,Junqing Cui,Yasuhiko Koezuka,Isao Toura,Yoshikatsu Kaneko,Kazuhiro Motoki,Hitomi Ueno,Ryusuke Nakagawa,Hiroshi Sato,Eisuke Kondo,Haruhiko Koseki,Masaru Taniguchi +11 more
TL;DR: Glycosylceramide-mediated proliferative responses of Valpha14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein.
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Journal ArticleDOI
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