Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
Citations
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Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages.
Chun Chou,Ming O. Li +1 more
TL;DR: An overview of the heterogeneous tissue-resident lymphocyte populations is provided, their development is discussed, and their functions both in the context of microbial infection and cancer are highlighted.
Journal ArticleDOI
Turned on by danger: activation of CD1d-restricted invariant natural killer T cells.
TL;DR: This work has characterized precisely how iNKT cells are activated by exogenous antigen, or by a combination of dendritic cell‐derived interleukin‐12 andiNKT TCR–self‐antigen–CD1d engagement, and is informing the design of synthetic iN KT‐cell antigens.
Journal ArticleDOI
Structure-activity relationship studies of novel glycosphingolipids that stimulate natural killer T-cells.
TL;DR: A large number of analogs of KRN7000 show potent bioactivities and have the potential of being utilized as therapeutic agents, and structure-activity relationship studies of novel glycolipids which stimulate NKT cells efficiently are summarized.
Journal ArticleDOI
The processing and presentation of lipids and glycolipids to the immune system
TL;DR: The overall sequence of events needed for efficient presentation of lipid antigens is now understood and presented and new approaches to address them are described during the characterization of lipids and glycolipids antigen presentation.
Journal ArticleDOI
Development and function of murine RORγt+ iNKT cells are under TGF-β signaling control.
TL;DR: This work demonstrates that both the development and responsiveness of the newly described IL-17-producing iNKT cell subset is under the control of a dedicated TGF-β signaling pathway.
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Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
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