Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
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Journal ArticleDOI
Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor
Piotr Humeniuk,Sabine Geiselhart,Claire Battin,Tonya J. Webb,Peter Steinberger,Wolfgang Paster,Karin Hoffmann-Sommergruber +6 more
TL;DR: A novel iN KT reporter platform is created which facilitates the identification of antigenic structures that drive the activation of iNKT cells in health and disease and is characterized by a shorter turnaround time and lower costs.
Dissertation
Mécanismes cellulaires et moléculaires de l’immunodépression post-infectieuse
TL;DR: Ce travail introduit des perspectives nouvelles dans la physiopathologie de l’immunodepression post-infectieuse et suggere des applications therapeutiques potentielles.
Journal ArticleDOI
Inappropriate activation of invariant natural killer T cells and antigen‐presenting cells with the elevation of HMGB1 in preterm births without acute chorioamnionitis
Masahiko Kato,Yasuyuki Negishi,Yoshio Shima,Yoshimitsu Kuwabara,Rimpei Morita,Toshiyuki Takeshita +5 more
TL;DR: Analysis of immune cells in the decidua of early to moderate PB without aCAM found that innate immunity and sterile inflammation are causes of PB in the absence of aC CAM.
Journal ArticleDOI
Harnessing the Versatility of Invariant NKT Cells in a Stepwise Approach to Sepsis Immunotherapy.
TL;DR: A double-hit treatment is designed that allows iNKT cells to escape anergy and exert beneficial effects in biphasic sepsis and may have translational potentials in the development of new therapies.
Journal ArticleDOI
Ether-linked lipids of Dermabacter hominis, a human skin actinobacterium.
Pedro L. Valero-Guillén,Isabel Fernández-Natal,Teresa Marrodan-Ciordia,Andreas Tauch,Francisco Soriano +4 more
TL;DR: The results demonstrate the existence of ether-linked lipids in D. hominis and reveal a differential distribution of phospholipids and glycolipids according to the sensitivity or resistance to daptomycin, although the mechanism(s) operating in the resistance to the antibiotic remain to be elucidated.
References
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Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
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