Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
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Miscarriage induced by adoptive transfer of dendritic cells and invariant natural killer T cells into mice.
TL;DR: It is demonstrated that the adoptive transfer of DEC‐205+ bone marrow‐derived DCs cocultured with α‐GalCer directly induced marked fetal loss by syngeneic pregnant C57BL/6 (B6) mice and allogeneic mice and was accompanied by the accumulation of activated iNKT cells in the myometrium.
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Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?
TL;DR: The characteristics of NKT cells are summarized, an update is given about their role and the progress that has been made in the field of multiple myeloma (MM), and some challenges are discussed that are currently hampering further progress.
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Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance.
Nagatoshi Fujiwara,Steven A. Porcelli,Takashi Naka,Ikuya Yano,Shinji Maeda,Hirotaka Kuwata,Shizuo Akira,Satoshi Uematsu,Satoshi Uematsu,Takemasa Takii,Hisashi Ogura,Kazuo Kobayashi +11 more
TL;DR: The results indicate that activation of the TLR4-dependent pathway of BMMs by SPLs induced an innate immune response and contributed to bacterial clearance.
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Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses.
Zuolong Chen,Shasha Zhu,Lu Wang,Di Xie,Huimin Zhang,Xiang Li,Xihua Zheng,Zhiwei Du,Jie Li,Li Bai +9 more
TL;DR: It is demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helpers iN KT (iNKTFH) cells and their interactions with memory B cells in recall responses.
Journal ArticleDOI
Functions of CD1d-Restricted Invariant Natural Killer T Cells in Antimicrobial Immunity and Potential Applications for Infection Control.
Yuki Kinjo,Shogo Takatsuka,Naoki Kitano,Shun Kawakubo,Masahiro Abe,Keigo Ueno,Yoshitsugu Miyazaki +6 more
TL;DR: The functions of CD1d-restricted iNKT cells in immune responses against microbial pathogens are summarized and the potential applications of glycolipid-mediated iN KT cell activation for preventing and controlling microbial infections are described.
References
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Journal Article
Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC.
TL;DR: Although universal screening for GBS colonization is anticipated to result in further reductions in the burden of GBS disease, the need to monitor for potential adverse consequences of intrapartum antibiotic use, such as emergence of bacterial antimicrobial resistance or increased incidence or severity of non-GBS neonatal pathogens, continues.
Journal ArticleDOI
Innate Immunity: The Virtues of a Nonclonal System of Recognition
TL;DR: Characterization of the nonclonal receptors of the innate immune system responsible for the adjuvant activity, and, evidently, for the associated side effects, would provide a powerful alternative approach, which would ultimately allow one to target these receptors directly.
Journal ArticleDOI
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.
Tetsu Kawano,Junqing Cui,Yasuhiko Koezuka,Isao Toura,Yoshikatsu Kaneko,Kazuhiro Motoki,Hitomi Ueno,Ryusuke Nakagawa,Hiroshi Sato,Eisuke Kondo,Haruhiko Koseki,Masaru Taniguchi +11 more
TL;DR: Glycosylceramide-mediated proliferative responses of Valpha14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein.
Journal ArticleDOI
The global burden of group A streptococcal diseases
TL;DR: The need to reinforce current control strategies, develop new primary prevention strategies, and collect better data from developing countries for most diseases is highlighted, as GAS is an important cause of morbidity and mortality.
Journal ArticleDOI
Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates
Katherine L. O'Brien,Lara J. Wolfson,James P. Watt,Emily Henkle,Maria Deloria-Knoll,Natalie McCall,Ellen Lee,Kim Mulholland,Orin S. Levine,Thomas Cherian +9 more
TL;DR: The burden of pneumococcal pneumonia is measured by applying the proportion of pneumonia cases caused by S pneumoniae derived from efficacy estimates from vaccine trials to WHO country-specific estimates of all-cause pneumonia cases and deaths, using disease incidence and case-fatality data from a systematic literature review.
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