Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
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Journal ArticleDOI
Invariant Natural Killer T Cells
TL;DR: iNKT cells are a very interesting subset of T cells that may bridge the innate and adaptive immune systems, however, their TCR evolved to recognize different glycolipid antigens in a conserved manner and to perform innate-like rather than adaptive functions.
Journal ArticleDOI
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation
Étienne Doré,Charles Joly-Beauparlant,Satoshi Morozumi,Alban Mathieu,Tania Lévesque,Isabelle Allaeys,Anne-Claire Duchez,Nathalie Cloutier,Mickael Leclercq,Antoine Bodein,Christine Payré,Cyril Martin,Agnès Petit-Paitel,Michael H. Gelb,Manu Rangachari,Makoto Murakami,Laetitia Davidovic,Nicolas Flamand,Makoto Arita,Gérard Lambeau,Arnaud Droit,Eric Boilard +21 more
TL;DR: The data suggest that a singular protein, sPLA2-IIA, produces systemic effects on the immune system through its activity on the microbiota and its lipidome, and that this activity could profoundly alter the fecal lipidome.
Journal ArticleDOI
SLAM-associated protein favors the development of iNKT2 over iNKT17 cells.
Marie Laure Michel,Christelle Lenoir,Bérangère Massot,Séverine Diem,Benoit Pasquier,Shinichiro Sawa,Rachel Rignault-Bricard,Agnès Lehuen,Gérard Eberl,André Veillette,Maria Leite-de-Moraes,Sylvain Latour +11 more
TL;DR: It is found that SAP is critical not only for IL‐4 production but also for the terminal differentiation of IL‐ 4‐producing iNKT2 cells, and a new critical regulatory function for SAP is unveiled in thymic iN KT cell fate decisions.
Journal ArticleDOI
T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells.
TL;DR: Recent findings focusing on the role of TCR-mediated signaling are summarized and possible mechanisms that may influence the sub-lineage choice of iNKT cells are discussed.
Journal ArticleDOI
Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming
Taryn L. Osmond,Kathryn J. Farrand,Gavin F. Painter,Christiane Ruedl,Troels R. Petersen,Ian F. Hermans,Ian F. Hermans +6 more
TL;DR: It is suggested that different DC subsets can contribute to T cell priming if provided appropriately phased activatory stimuli, an observation that could be factored into the design of more effective vaccines.
References
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