Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
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TLDR
The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.Abstract:
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.read more
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Journal ArticleDOI
iNKT Cells and Their Potential Lipid Ligands during Viral Infection
TL;DR: Pro-inflammatory signals produced during viral infection may stimulate iNKT cells through enhanced CD1d-dependent endogenous lipid presentation, which may alter lipid composition and inhibit endogenous lipid degradation.
Journal ArticleDOI
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin
Espen Melum,Espen Melum,Xiaojun Jiang,Kirsti B Baker,Kirsti B Baker,M. Fatima Macedo,M. Fatima Macedo,M. Fatima Macedo,Jürgen Fritsch,Jürgen Fritsch,C. Marie Dowds,Jing Wang,Anne Pharo,Arthur Kaser,Corey Tan,Corey Tan,Catia S. Pereira,Catia S. Pereira,Samuel Kelly,Jingjing Duan,Jingjing Duan,Tom H. Karlsen,Mark A. Exley,Stefan Schütze,Dirk M. Zajonc,Dirk M. Zajonc,Alfred H. Merrill,Edward H. Schuchman,Sebastian Zeissig,Sebastian Zeissig,Richard S. Blumberg +30 more
TL;DR: It is shown that control of non-agonistic CD1d-associated lipids is critical for iNKT cell development and function in vivo and represents a tight link between cellular sphingolipid metabolism and immunity.
Journal ArticleDOI
Enhancement of Oral Tolerance Induction in DO11.10 Mice by Lactobacillus gasseri OLL2809 via Increase of Effector Regulatory T Cells.
Ayako Aoki-Yoshida,Ayako Aoki-Yoshida,Kiyoshi Yamada,Satoshi Hachimura,Toshihiro Sashihara,Shuji Ikegami,Makoto Shimizu,Mamoru Totsuka +7 more
TL;DR: Oral administration of LG2809 increases the population of pDCs in the LP, resulting in the enhancement of oral tolerance induction by increasing the ratio of effector regulatory T cells, which could act as a potent immunomodulator to prevent food allergies by promoting oral tolerance.
Journal ArticleDOI
Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model.
TL;DR: In vivo GO treatment substantially inhibited the capacity of α-GalCer to induce the iNKT cell-mediated trans-activation of and cytokine production by innate and innate-like cells, including DCs, macrophages, NK cells, and γδ T cells.
Journal ArticleDOI
Invariant natural killer T cells and their ligands: focus on multiple sclerosis
TL;DR: The list of relevant stimulatory lipids and glycolipid antigens now includes a range of endogenous self‐antigens including the myelin‐derived acetylated galactosylceramides, likely to foster the development of therapeutic strategies aimed at harnessing iNKT cell activity.
References
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