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Long non-coding RNAs: new players in cell differentiation and development
Alessandro Fatica,Irene Bozzoni +1 more
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TLDR
The function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development are described.Abstract:
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.read more
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Invited Review: Long non-coding RNAs: important regulators in the development, function and disorders of the central nervous system.
TL;DR: The general characteristics, localization and classification of lncRNAs are described and examples of the molecular mechanisms of nuclear and cytoplasmic lncRNA actions in the CNS are elucidated and discussed.
Journal ArticleDOI
Crosstalk between long non-coding RNAs and Wnt/β-catenin signalling in cancer.
Gang Yang,Tianyi Shen,Xiaoming Yi,Zhengyu Zhang,Chaopeng Tang,Longxin Wang,Yulin Zhou,Wen-Quan Zhou,Wen-Quan Zhou +8 more
TL;DR: Targeting lncRNAs or/and molecules associated with the Wnt/β‐catenin signalling pathway may be a feasible therapeutic method in the future after emerging evidences have suggested that lnc RNAs can interact with several components of the WNT/β-caten in signalling pathway to regulate the expression of Wnt target genes in cancer.
Journal ArticleDOI
Challenges in the analysis of long noncoding RNA functionality
Sergio Leone,Raffaella Santoro +1 more
TL;DR: The strengths and weaknesses of available techniques for the analysis of chromatin‐associated lncRNA and emerging models for the recruitment to specific genomic sites such as triple‐helix, RNA–protein–DNA recognition and proximity‐guided search models are discussed.
Journal ArticleDOI
RNCR3: A regulator of diabetes mellitus-related retinal microvascular dysfunction
TL;DR: The role of lncRNA-RNCR3 in diabetes mellitus-induced retinal microvascular abnormalities is reported and it is shown that RNCR3 is significantly up-regulated upon high glucose stress in vivo and in–vitro.
Journal ArticleDOI
Comparative analysis of DNA methylome and transcriptome of skeletal muscle in lean-, obese-, and mini-type pigs.
Yalan Yang,Guoming Liang,Guanglin Niu,Yuanyuan Zhang,Rong Zhou,Yanfang Wang,Yulian Mu,Zhonglin Tang,Kui Li +8 more
TL;DR: In this article, a comparative analysis of skeletal muscle was carried out by integrating analysis of genome-wide DNA methylation, mRNA, lncRNA and miRNA profiles in three different pig breeds (obese-type Tongcheng, lean-type Landrace, and mini-type Wuzhishan pigs).
References
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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