Journal ArticleDOI
Long non-coding RNAs: new players in cell differentiation and development
Alessandro Fatica,Irene Bozzoni +1 more
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TLDR
The function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development are described.Abstract:
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.read more
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Journal ArticleDOI
Single-cell RNA-seq analysis of mouse preimplantation embryos by third-generation sequencing.
Xiaoying Fan,Dong Tang,Yuhan Liao,Pidong Li,Yu Zhang,Minxia Wang,Fan Liang,Xiao Wang,Yun Gao,Lu Wen,Depeng Wang,Yang Wang,Fuchou Tang,Fuchou Tang +13 more
TL;DR: Wang et al. as discussed by the authors developed a novel scRNA-seq technology based on third-generation sequencing (TGS) platform (single-cell amplification and sequencing of full-length RNAs by Nanopore platform, SCAN-seq).
Journal ArticleDOI
Long Non-coding RNA CCAT1 Sponges miR-454 to Promote Chemoresistance of Ovarian Cancer Cells to Cisplatin by Regulation of Surviving
De-Ying Wang,Na Li,Yu-Lan Cui +2 more
TL;DR: The data revealed that silencing of CCAT1 promoted cisplatin-induced apoptosis via modulating the expression of pro- or anti-apoptotic proteins Bax, Bcl-2, and survivin.
Journal ArticleDOI
LncSHRG promotes hepatocellular carcinoma progression by activating HES6
Yingchen Xu,Chaojie Liang,Dongxin Zhang,Guanqun Li,Gao Xia,Jianzhu Fu,Feng Xia,Jiajun Ji,Li-Jun Zhang,Guangming Li,Jixiang Wu +10 more
TL;DR: It is found that a long noncoding RNA, lncSHRG, was greatly upregulated in human hepatocellular carcinoma samples and was essential for liver cancer cell proliferation and tumor propagation in mice.
Book ChapterDOI
Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming.
TL;DR: This chapter discusses the regulatory roles of noncoding RNAs on cancer metabolism and its underlying regulatory mechanisms are still poorly understood.
Journal ArticleDOI
Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loop.
Hua Jiang,Yingzhun Chen,Tong Yu,Xiaoguang Zhao,Huitong Shan,Jian Sun,Lu Zhang,Xuelian Li,Hongli Shan,Haihai Liang +9 more
TL;DR: Findings indicate that lncRNA PFRL contributes to the progression of lung fibrosis by modulating the reciprocal repression between miR-26a and Smad2 and that this lncRNAs may be a therapeutic target for IPF.
References
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Journal ArticleDOI
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Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
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Journal ArticleDOI
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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