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Long non-coding RNAs: new players in cell differentiation and development
Alessandro Fatica,Irene Bozzoni +1 more
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TLDR
The function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development are described.Abstract:
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.read more
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LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK.
Xinxin Si,Ruochen Zang,Erbao Zhang,Yue Liu,Xiao Shi,Ershao Zhang,Lipei Shao,Andi Li,Nan Yang,Xiao Han,Beijing Pan,Zhihong Zhang,Luan Sun,Yujie Sun +13 more
TL;DR: The data suggest that the ERα-H19-BIK signaling axis plays an important role in promoting chemoresistance, and altered ERα expression may change H19 levels to modulate the apoptosis response to chemotherapy in breast cancer cells.
Journal ArticleDOI
Non-coding RNAs in cardiovascular cell biology and atherosclerosis.
TL;DR: Together, clinicopathological findings and studies in animal models have elucidated the multifaceted and frequently divergent effects non-coding RNAs impose both directly and indirectly on the formation and progression of atherosclerosis.
Journal ArticleDOI
Recent advancement and strategy on bio-hydrogen production from photosynthetic microalgae.
TL;DR: Recent approaches on new molecular genetics engineering and metabolic pathway developments, modern photo-bioreactors efficiency, economic assessment, limitations and knowledge gap of bio-hydrogen production from microalgae are discussed.
Journal ArticleDOI
The Immune Functions of Keratinocytes in Skin Wound Healing.
TL;DR: This review focuses on the communications between keratinocytes and immune cells in wound healing, which are mediated by various cytokines, chemokines, and extracellular vesicles.
Journal ArticleDOI
Long non-coding RNA ADNCR suppresses adipogenic differentiation by targeting miR-204
Mingxun Li,Xiaomei Sun,Hanfang Cai,Yujia Sun,Martin Plath,Congjun Li,Xianyong Lan,Chuzhao Lei,Lin Fengpeng,Yueyu Bai,Hong Chen +10 more
TL;DR: Ribo-Zero RNA-Seq data provide a valuable genomic resource for the identification of lncRNAs with functional roles in adipocyte differentiation but also reveal new insights into understanding the mechanisms of adipogenic differentiation.
References
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