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Long non-coding RNAs: new players in cell differentiation and development
Alessandro Fatica,Irene Bozzoni +1 more
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TLDR
The function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development are described.Abstract:
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.read more
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Multidimensional communication of microRNAs and long non-coding RNAs in lung cancer.
TL;DR: In this paper, a review of the latest research on the link between miRNAs and lncRNAs in lung cancer is presented, which discusses their potential role as diagnostic biomarkers and therapeutic targets for lung cancer in clinical practice.
Journal ArticleDOI
Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets?
TL;DR: An overview of recent findings regarding the emerging role of lncRNAs not only as key regulators of cancer initiation and progression in colon, stomach, pancreatic, liver, and esophageal cancers, but also as reliable tumor markers and therapeutic tools is provided.
Journal ArticleDOI
Long noncoding RNA H19 acts as a miR-29b sponge to promote wound healing in diabetic foot ulcer.
TL;DR: Upregulation of lncRNA H19 can elevate the expression of FBN1 through competitively binding to miR‐29b, which enhances the proliferation, migration, and inhibits apoptosis of fibroblasts, thus facilitating the wound healing of DFU.
Journal ArticleDOI
LINC00702/miR-4652-3p/ZEB1 axis promotes the progression of malignant meningioma through activating Wnt/β-catenin pathway.
TL;DR: Bioinformatics analysis and mechanism experiments demonstrated that LINC00702 acted as the molecular sponge of miR-4652-3p to upregulate ZEB1 in malignant meningioma, and high level of LINC 00702 was demonstrated to be associated with the activity of Wnt/β-catenin signaling.
Journal ArticleDOI
The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma.
Po-Shuan Huang,I-Hsiao Chung,Yang-Hsiang Lin,Yang-Hsiang Lin,Tzu-Kang Lin,Wei-Jan Chen,Kwang-Huei Lin,Kwang-Huei Lin,Kwang-Huei Lin +8 more
TL;DR: Findings support a potential role for MIR503HG in cancer cell proliferation through the miR-503/Smurf2/TGFBR axis and indicate that MIR 503HG is a potential marker in ALK-negative ALCL.
References
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Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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